| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BTB/POZ domain-containing protein KCTD15, Potassium channel tetramerization domain-containing protein 15, KCTD15 |
| Entrez GeneID | 79047 |
| WB Predicted band size | 31.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This KCTD15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the C-terminal region of human KCTD15. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KCTD15抗体的3篇代表性文献示例(注：文献信息为模拟示例，具体内容可能需要根据实际研究调整)：
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1. **文献名称**: *KCTD15 modulates neural crest specification by regulating Wnt/β-catenin signaling*
**作者**: Patterson et al.
**摘要**: 研究利用KCTD15抗体在小鼠胚胎中定位蛋白表达，发现KCTD15通过抑制Wnt/β-catenin信号通路调控神经嵴细胞分化，抗体用于免疫荧光染色和Western blot验证蛋白表达水平。
2. **文献名称**: *KCTD15 acts as a tumor suppressor in gastric cancer by targeting EGFR degradation*
**作者**: Zhang et al.
**摘要**: 通过KCTD15抗体进行免疫组化分析，发现KCTD15在胃癌组织中低表达，其缺失促进EGFR信号激活和肿瘤进展，研究提示KCTD15可能通过泛素化降解EGFR抑制癌症。
3. **文献名称**: *KCTD15 interacts with transcription factors to repress adipogenesis*
**作者**: Li et al.
**摘要**: 使用KCTD15抗体在3T3-L1脂肪细胞中证实其与AP-2α的相互作用，揭示KCTD15通过抑制脂肪生成关键转录因子调控代谢平衡，抗体应用于免疫共沉淀(Co-IP)和细胞定位实验。
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如需具体文献，建议在PubMed或Google Scholar中以“KCTD15 antibody”或“KCTD15 function”为关键词检索，筛选涉及实验方法学(如Western blot、IHC等)的论文。
The KCTD15 (Potassium Channel Tetramerization Domain Containing 15) antibody is a tool used to detect and study the KCTD15 protein, a member of the KCTD family characterized by a conserved N-terminal BTB/POZ domain. KCTD15 is involved in diverse biological processes, including transcriptional regulation and protein-protein interactions. It plays a role in developmental signaling pathways, notably acting as a negative regulator of the Hedgehog (Hh) and Wnt pathways, which are critical for embryonic patterning, cell differentiation, and tissue homeostasis. Studies link KCTD15 to neural crest development, adipogenesis, and cancer progression, with implications in obesity, neurodevelopmental disorders, and tumorigenesis.
KCTD15 antibodies are typically polyclonal or monoclonal, generated in hosts like rabbits or mice, and validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies target specific epitopes, enabling researchers to investigate KCTD15's expression patterns, subcellular localization, and interactions (e.g., with cullin-3 to form E3 ubiquitin ligase complexes). Dysregulation of KCTD15 has been observed in cancers like glioblastoma and melanoma, as well as metabolic syndromes, making its study clinically relevant. The antibody serves as a key reagent in elucidating KCTD15's molecular mechanisms and potential therapeutic applications.
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