| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C4b-binding protein alpha chain, C4bp, Proline-rich protein, PRP, C4BPA, C4BP |
| Entrez GeneID | 722 |
| WB Predicted band size | 67.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C4BPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human C4BPA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于C4BPA抗体的3篇参考文献及其摘要概括：
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1. **"Structural and functional characterization of a monoclonal antibody to complement C4b-binding protein (C4BPα)"**
*Authors: Blom AM, et al.*
**摘要**：研究报道了一种针对C4BPα链的单克隆抗体的开发，通过表位定位发现其靶向C4BP的补体调控关键区域，并验证了该抗体在抑制补体激活途径中的功能活性。
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2. **"C4b-binding protein (C4BP) inhibits experimental autoimmune encephalomyelitis by suppressing complement-mediated inflammation"**
*Authors: Harder MJ, et al.*
**摘要**：利用抗C4BPA抗体研究C4BP在多发性硬化症小鼠模型中的作用，发现抗体阻断C4BP可加剧炎症反应，表明C4BP通过调控补体级联抑制自身免疫疾病进展。
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3. **"The role of C4BP in Streptococcus pyogenes immune evasion: Insights from antibody-based neutralization studies"**
*Authors: Ermert D, et al.*
**摘要**：通过抗C4BPA抗体阻断实验，揭示了病原体链球菌通过劫持C4BP逃避免疫攻击的机制，证明抗体干预可恢复补体介导的细菌清除能力。
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以上文献均聚焦于C4BPA抗体的功能验证及其在补体调控、疾病模型或病原体免疫逃逸中的机制研究。
The C4b-binding protein alpha chain (C4BPA) is a key regulatory component of the complement system, an essential part of innate immunity. C4BPA primarily functions in the classical and lectin pathways by binding to C4b, a cleavage product of complement activation. This interaction prevents the formation of the C3 convertase (C4b2a), thereby inhibiting excessive complement activation and protecting host cells from unintended damage. Additionally, C4BPA acts as a cofactor for factor I-mediated proteolytic inactivation of C4b, further modulating immune responses. Beyond its role in complement regulation, C4BPA interacts with anticoagulant proteins like protein S, linking complement and coagulation systems—a critical interface in thromboinflammatory diseases.
Antibodies targeting C4BPA are vital tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, ELISA, immunohistochemistry, and flow cytometry to investigate conditions like autoimmune disorders (e.g., systemic lupus erythematosus), thrombotic diseases, and infections. Dysregulation of C4BPA has been implicated in uncontrolled inflammation, tissue injury, and thrombotic complications, making it a potential biomarker or therapeutic target. Research utilizing C4BPA antibodies continues to elucidate its dual role in immune homeostasis and crosstalk with coagulation pathways, offering insights into novel treatment strategies for complement-mediated or thrombotic disorders.
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