| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcium signal-modulating cyclophilin ligand, CAML, CAMLG, CAML |
| Entrez GeneID | 819 |
| WB Predicted band size | 33.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CAMLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the Central region of human CAMLG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CAMLG抗体的模拟参考文献示例(信息为模拟，仅供参考)：
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1. **文献名称**: **"CAMLG regulates endoplasmic reticulum-mitochondrial calcium flux in T cell activation"**
**作者**: Smith A, et al. (2021)
**摘要**: 本研究利用CAMLG特异性抗体，通过Western blot和共聚焦显微镜技术，揭示了CAMLG蛋白在T细胞活化过程中调控内质网-线粒体钙离子流动的关键作用，为免疫信号传导机制提供了新见解。
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2. **文献名称**: **"Development and validation of a monoclonal anti-CAMLG antibody for neurodegenerative disease research"**
**作者**: Chen L, et al. (2019)
**摘要**: 文章描述了一种高特异性抗CAMLG单克隆抗体的开发，并通过免疫组化验证其在阿尔茨海默病模型中的表达变化，表明CAMGL可能参与神经元钙稳态失调。
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3. **文献名称**: **"CAMLG expression correlates with tumor progression in colorectal cancer"**
**作者**: Kim H, et al. (2020)
**摘要**: 通过免疫组织化学分析结肠癌组织样本，研究使用抗CAMLG抗体发现其表达水平与肿瘤分期和转移风险呈正相关，提示其作为潜在生物标志物的价值。
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4. **文献名称**: **"CAMLG-mediated calcium signaling in endoplasmic reticulum stress response"**
**作者**: Rodriguez P, et al. (2018)
**摘要**: 利用CAMLG抗体进行免疫沉淀和功能实验，揭示了该蛋白在内质网应激反应中通过调控钙释放促进细胞凋亡的分子机制。
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注：以上内容为模拟生成，实际文献需通过学术数据库(如PubMed、Google Scholar)检索确认。
CAMLG (Calcium-Integral Membrane Protein Ligand) is a conserved eukaryotic protein primarily localized to the endoplasmic reticulum (ER) membrane. It plays a critical role in protein translocation and calcium signaling. CAMLG interacts with the Sec61 translocon complex, facilitating the co-translational insertion of nascent polypeptides into the ER membrane. It also modulates calcium homeostasis by regulating ER calcium release, influencing processes like apoptosis and cellular stress responses.
CAMLG antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate CAMLG's role in protein biogenesis, ER-associated degradation (ERAD), and calcium-dependent signaling pathways. Studies have linked CAMLG dysfunction to diseases, including certain cancers and neurodegenerative disorders, where ER stress and protein misfolding are implicated. For example, altered CAMLG expression has been observed in glioblastoma and Alzheimer's disease models, suggesting its potential as a therapeutic or diagnostic target. These antibodies also help explore CAMLG's involvement in immune cell development, particularly B-cell maturation, where ER protein processing is crucial. Commercial CAMLG antibodies are typically raised against specific epitopes, such as human CAMLG's N-terminal region, ensuring specificity across human and model organism samples (e.g., mice, rats).
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