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Rabbit Polyclonal KPRA(N-term) Antibody

  • 中文名： KPRA (N-term)抗体
  • 别    名： Phosphoribosyl pyrophosphate synthase-associated protein 1, PRPP synthase-associated protein 1, 39 kDa phosphoribosypyrophosphate synthase-associated protein, PAP39, PRPSAP1
货号: IPDX30765
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPhosphoribosyl pyrophosphate synthase-associated protein 1, PRPP synthase-associated protein 1, 39 kDa phosphoribosypyrophosphate synthase-associated protein, PAP39, PRPSAP1
Entrez GeneID5635
WB Predicted band size39.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis KPRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human KPRA.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇假设性的参考文献示例，供参考(注：KPRA抗体相关文献可能需通过学术数据库核实，以下为构造示例)：

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1. **文献名称**: "Development and Characterization of a Novel KPRA (N-term) Monoclonal Antibody for Detecting Apoptotic Cleavage Events"

**作者**: Thompson, R. et al.

**摘要**: 描述了一种针对KPRA蛋白N端表位的单克隆抗体的开发，通过重组蛋白免疫小鼠制备。抗体经WB、IF验证特异性，适用于检测细胞凋亡过程中KPRA的剪切片段，应用于乳腺癌细胞模型。

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2. **文献名称**: "KPRA-N-terminal Antibody Reveals Altered Expression in Neurodegenerative Disease Models"

**作者**: Lee, S. & Martinez, A.

**摘要**: 利用KPRA (N-term)多克隆抗体(兔源)研究其在阿尔茨海默病模型中的表达变化。抗体通过肽段免疫制备，验证了与脑组织样本的结合特异性，发现KPRA在病变神经元中异常聚集。

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3. **文献名称**: "A High-Affinity KPRA Antibody Targeting the N-terminal Domain for Immunohistochemical Applications"

**作者**: Gupta, P. et al.

**摘要**: 报道了一种高亲和力KPRA-N端抗体，优化用于福尔马林固定石蜡包埋(FFPE)组织的免疫组化。研究证实该抗体在结直肠癌组织中染色显著增强，提示KPRA作为潜在生物标志物。

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**建议**：实际文献需通过PubMed、Google Scholar等平台，以“KPRA antibody N-terminal”等关键词检索，并筛选近年高被引论文。

背景信息

The KPRA (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to recognize the N-terminal region of the KPRA protein, a less-characterized protein implicated in cellular processes such as signal transduction, transcriptional regulation, or post-translational modifications. The N-terminal epitope targeted by this antibody often corresponds to a unique sequence within the initial 100-200 amino acids of the protein, enabling specificity in detecting full-length KPRA or its isoforms. Such antibodies are typically generated in immunized hosts (e.g., rabbits, mice) using synthetic peptides or recombinant protein fragments derived from the N-terminal domain. KPRA antibodies are commonly validated for applications like Western blotting, immunofluorescence, or immunoprecipitation to study KPRA expression, localization, and interactions. While the exact biological role of KPRA remains under investigation, its involvement in pathways like cell proliferation, stress response, or metabolic regulation has been suggested in limited studies. Researchers utilize KPRA (N-term) antibodies to explore its tissue-specific expression, regulatory mechanisms (e.g., phosphorylation), or associations with diseases such as cancer or neurodegenerative disorders. Proper controls (e.g., knockout validation) are essential to confirm antibody specificity due to potential cross-reactivity with unrelated proteins sharing homologous N-terminal motifs.

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