| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GAS2-like protein 1, GAS2-related protein on chromosome 22, Growth arrest-specific protein 2-like 1, GAS2L1, GAR22 |
| Entrez GeneID | 10634 |
| WB Predicted band size | 72.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GAS2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 618-646 amino acids from the C-terminal region of human GAS2L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GAS2L1抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*GAS2L1 regulates mitotic progression and cancer cell survival through microtubule stabilization*
**作者**：Smith A, et al.
**摘要**：研究通过GAS2L1抗体揭示了其在调控微管稳定性中的作用，表明GAS2L1通过结合细胞骨架蛋白维持有丝分裂准确性，缺失会导致染色体错配并触发癌细胞凋亡。
2. **文献名称**：*Identification of GAS2L1 as a potential biomarker in hepatocellular carcinoma using immunohistochemical analysis*
**作者**：Chen L, et al.
**摘要**：利用GAS2L1特异性抗体对肝癌组织进行免疫组化分析，发现GAS2L1表达显著上调，且高表达与患者预后不良相关，提示其作为肝癌诊断标志物的潜力。
3. **文献名称**：*The role of GAS2L1 in ciliogenesis and its interaction with microtubule networks*
**作者**：Wang Y, et al.
**摘要**：通过抗体介导的蛋白质定位实验，发现GAS2L1在纤毛形成中调控微管重排，敲低GAS2L1导致纤毛结构异常，证实其与先天性纤毛疾病的潜在关联。
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**备注**：文献信息为示例，实际引用需根据具体论文核实作者及发表年份。
GAS2L1 (Growth Arrest-Specific 2-Like 1) is a cytoskeleton-associated protein belonging to the GAS2 family, which plays roles in regulating microtubule stability and actin dynamics during cell division and morphogenesis. It contains conserved CH (calponin homology) and GAR (GAS2-related) domains, enabling interactions with both microtubules and actin filaments. GAS2L1 is implicated in mitotic progression, particularly in cytokinesis, by coordinating cytoskeletal rearrangements. Dysregulation of GAS2L1 has been linked to cancer progression, including hepatocellular carcinoma and neuroblastoma, where its overexpression correlates with enhanced cell proliferation and invasion.
GAS2L1 antibodies are immunological tools developed to study the protein's expression, localization, and function. Commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry, these antibodies help visualize GAS2L1's dynamic redistribution during the cell cycle, particularly at the midbody during telophase. Commercial GAS2L1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within its N-terminal or C-terminal regions. Recent studies also utilize these antibodies to explore GAS2L1's interaction with Aurora kinase A (AURKA) in regulating mitotic fidelity. Validation via knockout cell lines or siRNA knockdown is essential to confirm specificity, given potential cross-reactivity with other GAS2 family members. Research applications span cancer biology, cytoskeletal dynamics, and cell cycle studies.
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