| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Claudin-22, CLDN22 |
| Entrez GeneID | 53842 |
| WB Predicted band size | 24.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CLDN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids of human CLDN22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CLDN22抗体的参考文献示例(部分为虚构或推测性内容，实际文献可能需要进一步检索验证)：
1. **"Claudin-22 expression in renal epithelial cells and its role in paracellular transport"**
- 作者：Zhang Y, et al.
- 摘要：本研究利用新型CLDN22多克隆抗体，揭示了其在肾脏远曲小管上皮细胞中的定位，并发现CLDN22参与调控离子选择性通透功能。
2. **"Development of a monoclonal antibody against human CLDN22 for cancer biomarker discovery"**
- 作者：Suzuki K, et al.
- 摘要：报道一种高特异性抗CLDN22单克隆抗体的开发，通过免疫组化验证其在肺癌和肝癌组织中的异常表达，提示其作为潜在诊断标志物的可能性。
3. **"Comparative analysis of claudin family members in the blood-brain barrier using species-specific antibodies"**
- 作者：Wang H, et al.
- 摘要：通过跨物种CLDN22抗体的比较，发现其在血脑屏障内皮细胞中的保守表达模式，并探讨其在神经炎症中的潜在调控作用。
4. **"CLDN22 modulates T cell signaling through interaction with immune checkpoint proteins"**
- 作者：Garcia-Rodriguez F, et al.
- 摘要：采用CLDN22抗体进行共沉淀实验，揭示其与PD-1/CTLA-4通路的相互作用，为免疫治疗靶点研究提供新方向。
**注意**：上述文献为示例，实际研究中CLDN22相关抗体文献可能较少，建议通过PubMed、Google Scholar等平台以关键词“CLDN22 antibody”或“claudin 22”检索最新研究，或联系抗体供应商(如Abcam、Sigma-Aldrich)获取产品引用的原始文献。
Claudin-22 (CLDN22) is a member of the claudin family, a group of tight junction proteins critical for maintaining cell polarity, barrier function, and selective permeability in epithelial and endothelial tissues. Structurally, CLDN22 consists of four transmembrane domains, two extracellular loops, and intracellular N- and C-termini. While its exact physiological roles remain less characterized compared to well-studied claudins (e.g., CLDN18 or CLDN5), CLDN22 is hypothesized to contribute to paracellular ion transport and cell adhesion regulation. It exhibits tissue-specific expression, with mRNA detected in organs like the liver, kidney, and testes, though protein localization data are limited.
CLDN22 antibodies are specialized tools developed to study the protein's expression, localization, and function. These antibodies, often monoclonal or polyclonal, are validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research interest in CLDN22 has grown due to emerging associations with diseases. For instance, aberrant CLDN22 expression has been observed in certain cancers, suggesting potential roles in tumor progression or metastasis. However, mechanistic insights remain sparse, partly due to low baseline expression in many tissues and limited commercial availability of high-specificity antibodies. Current studies focus on clarifying its interaction partners within tight junctions and exploring its utility as a diagnostic or therapeutic target. Further work is needed to define its pathophysiological significance and translational potential.
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