| WB | 1/1000 | Human, Mouse ,Hamster |
| IF | 咨询技术 | Human, Mouse ,Hamster |
| IHC | 1/100-1/500 | Human, Mouse ,Hamster |
| ICC | 技术咨询 | Human, Mouse ,Hamster |
| FCM | 1/10-1/50 | Human, Mouse ,Hamster |
| Elisa | 咨询技术 | Human, Mouse ,Hamster |
| Aliases | GTP-binding protein 2, GTPBP2 {ECO:0000312|EMBL:CAC362691} |
| Entrez GeneID | 54676 |
| WB Predicted band size | 65.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse ,Hamster |
| Immunogen | This GTPBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-564 amino acids from the C-terminal region of human GTPBP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GTPBP2抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *"GTPBP2 modulates mitochondrial dynamics and cellular energy metabolism through interaction with fusion proteins"*
**作者**: Li Y, et al.
**摘要**: 本研究利用特异性GTPBP2抗体进行免疫印迹和免疫荧光实验，发现GTPBP2通过调控线粒体融合蛋白MFN1/2的活性影响线粒体形态和细胞能量代谢，提示其在代谢疾病中的潜在作用。
2. **文献名称**: *"A novel GTPBP2 antibody reveals its role in neuronal development and survival"*
**作者**: Chen X, et al.
**摘要**: 开发了一种高灵敏度兔源多克隆抗体，用于检测GTPBP2在神经元中的表达，发现其通过调控mRNA稳定性参与神经突触形成和细胞存活，为神经退行性疾病研究提供新工具。
3. **文献名称**: *"GTPBP2 deficiency disrupts ribosome biogenesis and leads to developmental defects in zebrafish"*
**作者**: Wang T, et al.
**摘要**: 通过构建GTPBP2基因敲除斑马鱼模型，结合抗体验证蛋白表达缺失，揭示GTPBP2在核糖体组装和胚胎发育中的关键作用，为相关遗传病机制提供依据。
(注：以上文献为示例，实际引用需根据具体研究补充真实来源。)
GTPBP2 (GTP-binding protein 2) is a member of the GTPase protein family, characterized by its conserved GTP-binding domain, which enables it to hydrolyze GTP and participate in cellular processes such as signal transduction, ribosome biogenesis, and stress response. This protein is evolutionarily conserved and plays roles in maintaining cellular homeostasis, particularly under stress conditions. Studies suggest GTPBP2 interacts with ribosomes and mitochondria, implicating it in translation regulation, energy metabolism, and apoptosis. Dysregulation of GTPBP2 has been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), and certain cancers, highlighting its potential as a therapeutic target or biomarker.
GTPBP2 antibodies are essential tools for detecting and quantifying GTPBP2 expression in research. They enable investigations into its localization (e.g., cytoplasmic, mitochondrial), expression levels across tissues, and interactions with other proteins. Commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence, these antibodies help elucidate GTPBP2’s role in cellular stress responses, disease mechanisms, and developmental processes. Recent studies also utilize GTPBP2 antibodies to explore its involvement in RNA metabolism and mitochondrial dysfunction, offering insights into pathological pathways. Validated antibodies with high specificity are critical to avoid cross-reactivity with homologous GTPases, ensuring accurate experimental outcomes in both basic and translational research contexts.
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