| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | F-box only protein 2, FBXO2, FBX2 |
| Entrez GeneID | 26232 |
| WB Predicted band size | 33.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FBXO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-271 amino acids from the C-terminal region of human FBXO2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与FBXO2抗体相关的参考文献概览：
1. **"FBXO2 mediates glycoprotein substrate recognition in the ubiquitin-proteasome pathway"**
*作者：Yoshida et al.*
**摘要**：研究利用FBXO2抗体进行免疫共沉淀和Western blot分析，揭示了FBXO2通过识别N-连接糖基化修饰的底物蛋白，调控其泛素化降解的分子机制，提示其在细胞质量控制中的关键作用。
2. **"FBXO2 expression is associated with tumor progression in hepatocellular carcinoma"**
*作者：Li et al.*
**摘要**：通过免疫组化及Western blot(使用FBXO2抗体)，发现FBXO2在肝癌组织中高表达，且与患者预后不良相关。研究进一步证明FBXO2通过促进致癌蛋白稳定性驱动肿瘤侵袭。
3. **"The F-box protein FBXO2 interacts with phosphorylated tau and regulates its degradation in Alzheimer's disease models"**
*作者：Wang et al.*
**摘要**：采用FBXO2抗体进行免疫荧光和蛋白质相互作用分析，发现FBXO2与磷酸化tau蛋白结合并促进其泛素化降解，为阿尔茨海默病中tau病理积累机制提供了新视角。
*注：以上文献信息为模拟示例，实际引用需核对具体期刊及作者准确性。建议通过PubMed或Google Scholar以“FBXO2 antibody”为关键词检索最新研究。*
The FBXO2 antibody is a crucial tool for studying the F-box protein 2 (FBXO2), a member of the F-box protein family that serves as a substrate-recognition component of the Skp1-Cullin-F-box (SCF) E3 ubiquitin ligase complex. FBXO2. also known as FBG1 or NFB42. is characterized by its F-box domain and a carbohydrate-binding domain (CBM), enabling it to target glycoproteins for ubiquitination and subsequent proteasomal degradation. This protein is predominantly expressed in secretory tissues such as the liver, pancreas, and testes, where it plays a role in endoplasmic reticulum-associated degradation (ERAD) by recognizing N-linked glycans on misfolded or unassembled glycoproteins.
Research highlights FBXO2's involvement in cellular quality control, immune regulation, and cancer progression. Dysregulation of FBXO2 has been linked to neurodegenerative diseases, including Alzheimer’s, where impaired protein clearance contributes to pathogenesis. In oncology, FBXO2 exhibits dual roles—acting as a tumor suppressor in some contexts (e.g., ovarian cancer) while promoting oncogenesis in others (e.g., hepatocellular carcinoma) by modulating key substrates like p21. cyclin D1. or EGFR. The FBXO2 antibody is widely utilized in techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate its expression, localization, and interaction networks. Its application extends to drug discovery, particularly in identifying therapeutic agents targeting FBXO2-associated pathways. Validation of FBXO2 antibodies is critical, as specificity ensures accurate interpretation of its regulatory mechanisms in health and disease.
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