关键信息
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基因名
HLA-DQB1
- 应用
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别名
CELIAC1; DQ beta 1 chain; DQB1_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen; DQ beta 1 chain; HLA class II histocompatibility antigen; DQ beta 2 chain; HLA DQB; HLA DQB1; HLA-DQB1; HLA-DQB2; IDDM1; Lymphocyte antigen; Major histocompatibility complex class II beta; Major histocompatibility complex; class II; DQ beta 1; MHC class II antigen DQB1; MHC class II antigen HLA DQ beta 1; MHC class II DQ beta chain; MHC class II HLA DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01920
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表达区间
33-227aa
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分子量
27 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
HLA-DQB1 is a crucial gene that encodes a protein involved in the immune system's major histocompatibility complex (MHC) class II molecules, which play a significant role in antigen presentation to T cells. Variations in the HLA-DQB1 gene are associated with various autoimmune diseases, such as type 1 diabetes, celiac disease, and multiple sclerosis, making it an important target for research. The study of HLA-DQB1 recombinant proteins has gained traction as researchers seek to understand how specific alleles contribute to disease susceptibility and to develop potential therapeutic strategies. By expressing and purifying recombinant HLA-DQB1 proteins, scientists can investigate their structure and function, evaluate their interactions with peptides and T cell receptors, and examine the role they play in immune responses. Additionally, recombinant proteins serve as valuable tools for diagnostic applications, vaccine development, and immunotherapy. Understanding the molecular mechanisms underpinning HLA-DQB1 variations will not only enhance our knowledge of immune system functions but may also lead to breakthroughs in personalized medicine, allowing for more effective treatments based on individual genetic profiles. Continuous advancements in protein engineering and expression systems further facilitate the exploration of HLA-DQB1's biological significance, making it a vital component in the fields of immunology and genetic research.
