关键信息
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基因名
H2-K1
- 应用
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别名
H2-K1; H2-K; H-2 class I histocompatibility antigen; K-D alpha chain; H-2K(D)
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种属
Mouse
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01902
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表达区间
22-305aa
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
H2-K1 is a class I major histocompatibility complex (MHC) molecule that plays a crucial role in the immune system by presenting endogenous peptides to CD8+ T cells, thereby influencing immune responses against intracellular pathogens and tumors. Research on H2-K1 recombinant proteins has gained significant attention due to their potential applications in immunotherapy and vaccine development. Understanding the structure and function of H2-K1 can provide insights into T cell recognition and activation mechanisms, which is essential for designing effective therapeutic strategies for cancers and infectious diseases. Additionally, H2-K1 serves as a model system for studying MHC-peptide interactions and the subsequent T cell response. Recent advancements in protein engineering and purification techniques have facilitated the generation of H2-K1 recombinant proteins, enabling detailed investigations into their stability, immunogenicity, and ability to elicit specific T cell responses. These studies are pivotal for harnessing H2-K1 in designing novel immunotherapeutic agents and improving our understanding of the immunological landscape in health and disease.
