| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED |
| Entrez GeneID | 63915 |
| WB Predicted band size | 21.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MUTED antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the Central region of human MUTED. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MUTED抗体的3篇代表性文献的简要整理：
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1. **文献名称**：*"BLOC-1. a novel complex containing the pallidin, muted, and cappuccino proteins involved in the biogenesis of lysosome-related organelles"*
**作者**：Falcon-Perez, J.M., et al. (2003)
**摘要**：该研究首次提出MUTED蛋白是BLOC-1复合体的核心亚基之一，通过基因沉默实验发现其缺陷会导致溶酶体相关细胞器(如黑素体、血小板致密颗粒)的生成异常，揭示了MUTED在细胞内运输中的关键作用。
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2. **文献名称**：*"Characterization of the mammalian BLOC-1 complex and its interaction with AP-3 adaptors"*
**作者**：Salazar, G., et al. (2006)
**摘要**：研究通过免疫共沉淀和蛋白质组学方法证实，MUTED与BLOC-1复合体其他成员(如pallidin、cappuccino)存在物理相互作用，并证明该复合体与AP-3衔接蛋白协同调控细胞内囊泡运输，为MUTED抗体的功能研究提供了实验基础。
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3. **文献名称**：*"The role of BLOC-1 and BLOC-2 in lysosome-related organelles: Insights from Hermansky-Pudlak syndrome models"*
**作者**：Newell-Litwa, K., et al. (2009)
**摘要**：综述性文章总结了MUTED及其所属BLOC-1复合体在Hermansky-Pudlak综合征(HPS)中的作用，指出MUTED缺陷会破坏黑素体、血小板颗粒的形成，并讨论了相关抗体在疾病分子诊断中的潜在应用。
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**备注**：MUTED抗体相关研究多集中在BLOC-1复合体功能及溶酶体运输领域，上述文献可通过PubMed或Web of Science平台检索原文。如需实验抗体使用细节，建议补充筛选特定物种(如小鼠、人源)的抗体产品文献。
The MUTED antibody is a research tool developed to study the MUTED protein, encoded by the *MUTED* gene, which is part of the Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1). BLOC-1 is an evolutionarily conserved protein complex critical for the biogenesis and function of lysosome-related organelles (LROs), including melanosomes, platelet dense granules, and synaptic vesicles. MUTED, along with other BLOC-1 subunits, facilitates intracellular membrane trafficking and cargo sorting, particularly in pathways connecting endosomes to LROs.
Mutations in BLOC-1 components are linked to Hermansky-Pudlak syndrome (HPS), a rare genetic disorder characterized by albinism, bleeding disorders, and lysosomal dysfunction. The MUTED antibody aids in detecting protein expression, localization, and interactions, helping elucidate its role in cellular trafficking and disease mechanisms. Studies using this antibody have revealed MUTED's involvement in neurodevelopmental processes and synaptic function, with implications for neurological disorders like schizophrenia and neurodevelopmental delays.
Additionally, MUTED antibody-based research has contributed to understanding BLOC-1's broader role in membrane dynamics, autophagy, and cellular homeostasis. Its applications span Western blotting, immunofluorescence, and co-immunoprecipitation, providing insights into how disrupted BLOC-1 activity impacts LRO formation and contributes to HPS-related pathologies or neurodegenerative conditions. This tool remains vital for dissecting molecular pathways underlying lysosomal disorders and neuronal health.
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