| WB | 1/1000 | Human, Mouse ,Hamster |
| IF | 咨询技术 | Human, Mouse ,Hamster |
| IHC | 咨询技术 | Human, Mouse ,Hamster |
| ICC | 技术咨询 | Human, Mouse ,Hamster |
| FCM | 咨询技术 | Human, Mouse ,Hamster |
| Elisa | 咨询技术 | Human, Mouse ,Hamster |
| Aliases | A-kinase-interacting protein 1, Breast cancer-associated gene 3 protein, PKA-interacting protein, Proline-rich protein BCA3, AKIP1, BCA3, C11orf17 |
| Entrez GeneID | 56672 |
| WB Predicted band size | 23.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse ,Hamster |
| Immunogen | This BCA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human BCA3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是基于常见研究主题构造的3篇示例文献参考(请注意为虚构示例，实际文献需通过学术数据库查询)：
---
1. **文献名称**: *"BCA3 interacts with PKM2 to regulate glycolysis in breast cancer cells"*
**作者**: Zhang L, et al.
**摘要**: 研究利用BCA3 (N-term)抗体进行免疫共沉淀，发现BCA3通过N端结构域与丙酮酸激酶PKM2结合，调控乳腺癌细胞糖酵解过程，促进肿瘤增殖。
2. **文献名称**: *"The role of BCA3 in HCV replication via JNK signaling pathway"*
**作者**: Tanaka K, et al.
**摘要**: 通过Western blot(使用BCA3 N-term抗体)和基因沉默技术，证实BCA3通过N端区域激活JNK通路，增强丙型肝炎病毒(HCV)的复制能力。
3. **文献名称**: *"BCA3 modulates androgen receptor signaling in prostate cancer"*
**作者**: Smith R, et al.
**摘要**: 利用BCA3 N端特异性抗体进行免疫组化分析，发现BCA3在前列腺癌中高表达，并通过与雄激素受体(AR)互作促进肿瘤耐药性形成。
---
**建议**：实际文献可通过以下关键词在PubMed或Google Scholar检索：
`"BCA3 antibody N-terminal"`、`"SH3BP5 antibody"`(BCA3别名)、`"BCA3 protein function"`。部分可能相关文献涉及BCA3在肿瘤代谢、病毒感染或信号转导中的作用。
The BCA3 (N-term) antibody targets the N-terminal region of BCA3 (Breast Cancer-Associated Gene 3), also known as PSIP1 (PC4 and SFRS1-interacting protein 1) or LEDGF (lens epithelium-derived growth factor). This multifunctional protein plays roles in transcriptional regulation, chromatin remodeling, and cellular stress responses. The N-terminal domain of BCA3 contains a PWWP chromatin-binding motif critical for its interaction with histone modifications and recruitment to sites of DNA damage.
BCA3 is implicated in cancer progression, particularly in breast cancer, where it may influence cell proliferation, apoptosis resistance, and metastasis. It also serves as a cofactor for HIV-1 integrase, facilitating viral DNA integration into host genomes. The BCA3 (N-term) antibody is widely used in research to study endogenous BCA3 expression, localization, and protein-protein interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its specificity for the N-terminal region makes it valuable for distinguishing BCA3 isoforms or assessing post-translational modifications in the C-terminal domain. Studies employing this antibody have contributed to understanding BCA3's dual roles in oncogenesis and viral pathogenesis, as well as its potential as a therapeutic target. Proper validation using knockout controls is recommended due to observed cross-reactivity with unrelated proteins in some experimental conditions.
×
