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Rabbit Polyclonal SC31B(C-term) Antibody

  • 中文名: SC31B (C-term)抗体
  • 别    名: Protein transport protein Sec31B, SEC31-like protein 2, SEC31-related protein B, SEC31B-1, SEC31B, SEC31L2
货号: IPDX30703
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein transport protein Sec31B, SEC31-like protein 2, SEC31-related protein B, SEC31B-1, SEC31B, SEC31L2
Entrez GeneID25956
WB Predicted band size128.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SC31B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1076-1104 amino acids from the C-terminal region of human SC31B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SC31B(C-term)抗体的模拟参考文献示例(注:以下内容为假设性示例,仅供参考):

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1. **文献名称**: *"Characterization of SC31B C-terminal Antibody for Specific Detection of Phosphorylated Isoforms in Neuronal Tissues"*

**作者**: Thompson L, et al. (2020)

**摘要**: 本研究开发了一种针对SC31B蛋白C末端磷酸化表位的多克隆抗体,验证了其在Western blot和免疫组化中的特异性。该抗体成功区分了阿尔茨海默病模型小鼠脑组织中SC31B的病理性与生理性磷酸化状态,为神经退行性疾病研究提供了工具。

2. **文献名称**: *"SC31B C-terminal Antibody Identifies a Novel Biomarker in Colorectal Cancer Progression"*

**作者**: Zhang Y, et al. (2018)

**摘要**: 通过SC31B C-term抗体检测发现,SC31B蛋白C末端片段在结直肠癌患者的肿瘤组织中异常高表达,且与患者预后不良相关。研究提示该抗体在癌症诊断和靶向治疗中具有潜在应用价值。

3. **文献名称**: *"Epitope Mapping of SC31B C-terminal Antibody Reveals Critical Residues for Protein-Protein Interaction"*

**作者**: Müller S, et al. (2019)

**摘要**: 利用丙氨酸扫描和ELISA技术,确定了SC31B C-term抗体识别的关键表位区域(氨基酸残基450-465)。该表位在SC31B与下游信号蛋白的结合中起重要作用,为功能研究提供了结构依据。

4. **文献名称**: *"Comparative Analysis of Commercial SC31B Antibodies Highlights C-terminal Specificity in Stress Granule Localization"*

**作者**: Park J, et al. (2021)

**摘要**: 本研究对比了多种SC31B抗体,发现C-term特异性抗体(如SC31B-C)可清晰标记应激颗粒中的SC31B蛋白,而N-term抗体则出现非特异性信号,强调了C端抗体在亚细胞定位研究中的可靠性。

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如需查找真实文献,建议通过以下方式:

- 在PubMed或Google Scholar搜索 **"SC31B antibody C-terminal"** 或 **"SC31B (C-term)"**;

- 查看抗体生产商(如Abcam、CST)的产品说明书,通常附有引用文献;

- 确认抗体的靶标蛋白全称及研究领域,以优化检索关键词。

背景信息

The SC31B (C-term) antibody is a polyclonal antibody generated to target the C-terminal region of a specific protein, often identified as part of research into cellular signaling pathways or structural proteins. While the exact target may vary depending on context, such antibodies are commonly designed to recognize epitopes near the carboxyl terminus, a region critical for protein-protein interactions, post-translational modifications, or functional activity. SC31B has been utilized in studies involving Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, localization, or cleavage events in various biological samples. Its specificity for the C-terminal domain makes it particularly valuable for distinguishing full-length proteins from truncated isoforms or degradation products, which is crucial in research areas like cancer biology, neurodegeneration, or apoptosis. Validation typically includes assays using knockout cell lines or siRNA-mediated knockdown to confirm target specificity. Researchers often employ this antibody to investigate disease-associated protein alterations, such as aberrant cleavage in pathological conditions or stress-induced modifications. As with many research antibodies, optimization of dilution ratios and experimental conditions is recommended to ensure reproducibility across applications.

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