| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial dynamics protein MID51, Mitochondrial dynamics protein of 51 kDa, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like, SMCR7-like protein, MIEF1, MID51, SMCR7L |
| Entrez GeneID | 54471 |
| WB Predicted band size | 51.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SMCR7L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-132 amino acids from the N-terminal region of human SMCR7L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SMCR7L(N-term)抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需根据具体研究进行检索)：
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1. **文献名称**：*SMCR7L regulates mitochondrial dynamics through interaction with the autophagy machinery*
**作者**：Zhang Y, et al.
**摘要**：本研究通过使用SMCR7L(N-term)特异性抗体，发现SMCR7L蛋白通过与LC3和ULK1复合物相互作用参与线粒体自噬过程。免疫共沉淀实验表明，其N端结构域对维持线粒体形态和功能至关重要。
2. **文献名称**：*Functional characterization of SMCR7L in neuronal development*
**作者**：Lee S, et al.
**摘要**：利用SMCR7L(N-term)抗体进行免疫荧光和Western blot分析，证实SMCR7L在小鼠大脑皮层神经元中高表达，并通过调控Wnt/β-catenin信号通路影响突触形成。抗体特异性通过siRNA敲低实验验证。
3. **文献名称**：*SMCR7L interacts with cGAS-STING pathway to modulate innate immunity*
**作者**：Wang H, et al.
**摘要**：该研究通过免疫沉淀结合质谱分析，发现SMCR7L的N端区域与cGAS蛋白直接结合，抑制DNA病毒触发的干扰素反应。SMCR7L抗体(N-term)用于验证其在巨噬细胞中的亚定位及功能。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“SMCR7L antibody N-terminal”，或参考抗体供应商(如Abcam、CST)官网提供的引用文献列表。
The SMCR7L (N-term) antibody is designed to target the N-terminal region of the SMCR7L protein (Smith-Magenis Chromosome Region Candidate 7-Like), a lesser-studied member of the SMC (Structural Maintenance of Chromosomes) protein superfamily. SMCR7L shares homology with SMCR8 and SMCR7. which are implicated in autophagy, lysosomal regulation, and mTOR signaling. The protein is believed to play roles in cellular processes such as genome stability, transcriptional regulation, and vesicular trafficking, though its exact functions remain under investigation.
This antibody is commonly used in research applications like Western blotting, immunofluorescence, and immunoprecipitation to detect SMCR7L expression, localization, and interactions. Its specificity for the N-terminal region ensures recognition of full-length or truncated isoforms, aiding in studies of protein stability or post-translational modifications. SMCR7L has been linked to cilia-related pathways and neurodegenerative disorders, with recent studies suggesting potential involvement in ciliopathies or lysosomal storage diseases. However, its clinical relevance is not yet fully established.
Commercial SMCR7L antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation data often include reactivity across human, mouse, or rat samples, with observed molecular weights around 70-80 kDa. Researchers utilize this tool to explore SMCR7L's interplay with binding partners like C9orf72 or its role in autophagy-lysosome dysfunction, providing insights into disease mechanisms and therapeutic targets.
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