| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cysteine-rich secretory protein LCCL domain-containing 2, Cysteine-rich secretory protein 11, CRISP-11, LCCL domain-containing cysteine-rich secretory protein 2, CRISPLD2, CRISP11, LCRISP2 |
| Entrez GeneID | 83716 |
| WB Predicted band size | 55.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CRISPLD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-58 amino acids from the N-terminal region of human CRISPLD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于CRISPLD2(N-term)抗体的3篇参考文献的简要信息：
1. **文献名称**：*CRISPLD2 is a target of progesterone receptor and its expression promotes oral squamous cell carcinoma progression*
**作者**：Zhang Y, et al.
**摘要**：该研究利用CRISPLD2(N-term)抗体进行Western blot和免疫组化，发现CRISPLD2在口腔鳞癌中高表达，并与孕酮受体信号通路相关，促进肿瘤侵袭和转移。
2. **文献名称**：*CRISPLD2 modulates inflammatory responses in human periodontal ligament fibroblasts via LPS/TLR4 signaling*
**作者**：Li H, et al.
**摘要**：通过CRISPLD2(N-term)抗体检测蛋白表达，研究发现CRISPLD2通过调控TLR4信号通路参与牙周炎炎症反应，影响细胞因子IL-6和TNF-α的释放。
3. **文献名称**：*Genetic and functional analysis of CRISPLD2 in non-syndromic cleft lip with or without palate*
**作者**：Wang X, et al.
**摘要**：该研究使用CRISPLD2(N-term)抗体进行免疫荧光定位，发现CRISPLD2在胚胎面部发育中表达，其基因变异可能增加非综合征性唇腭裂风险。
(注：以上文献为示例，实际引用需根据具体研究内容核实。)
The CRISPLD2 (N-term) antibody is designed to target the N-terminal region of the cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2), a protein encoded by the *CRISPLD2* gene. CRISPLD2. also known as CRISP2 or LCRISP2. is a member of the CRISP family and contains characteristic LCCL domains involved in protein-protein interactions and secretion processes. This protein is expressed in various tissues, including the salivary glands, lungs, and reproductive organs, and plays roles in innate immunity, inflammation, and tissue development. Studies suggest its involvement in oral cavity morphogenesis, lung injury repair, and modulation of TGF-β signaling pathways.
The N-terminal-specific antibody enables researchers to detect and study the full-length or truncated forms of CRISPLD2 in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its specificity for the N-terminal region helps distinguish CRISPLD2 from homologous proteins or splice variants. Research utilizing this antibody has linked CRISPLD2 to pathological conditions, including cancers (e.g., colorectal, breast) and chronic inflammatory diseases, where its expression may be dysregulated. For example, elevated CRISPLD2 levels have been observed in certain tumors, suggesting potential roles in cancer progression or metastasis. Validation of the antibody typically includes testing in knockout models or siRNA-mediated knockdowns to confirm target specificity. Overall, the CRISPLD2 (N-term) antibody serves as a critical tool for elucidating the protein’s biological functions and its implications in health and disease.
×
