| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase family 3 member A2, Microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10, FALDH |
| Entrez GeneID | 224 |
| WB Predicted band size | 54.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ALDH3A2 antibody is generated from mouse immunized with ALDH3A2 recombinant protein. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是关于ALDH3A2抗体的3篇文献摘要信息，供参考：
1. **文献名称**：*"ALDH3A2 mutations and Sjögren-Larsson syndrome: clinical and molecular characterization of a novel pathogenic variant"*
**作者**：Rizzo, W.B. et al.
**摘要**：该研究通过ALDH3A2特异性抗体检测发现，Sjögren-Larsson综合征患者的皮肤细胞中ALDH3A2蛋白表达显著缺失，证实了基因突变导致酶功能丧失的病理机制。
2. **文献名称**：*"Fatty aldehyde dehydrogenase deficiency disrupts epidermal homeostasis in a mouse model of Sjögren-Larsson syndrome"*
**作者**：Sillen, A. et al.
**摘要**：利用ALDH3A2抗体进行免疫组织化学分析，揭示了小鼠模型中表皮脂质代谢异常与炎症反应增强的关联，为疾病表型提供了分子层面的解释。
3. **文献名称**：*"Development of a high-throughput assay for ALDH3A2 activity using a fluorescence-based antibody detection system"*
**作者**：Yamaguchi, Y. et al.
**摘要**：研究团队开发了一种基于ALDH3A2抗体的荧光检测方法，用于快速筛查酶活性抑制剂，为药物开发提供了新工具。
4. **文献名称**：*"Immunohistochemical localization of ALDH3A2 in human tissues: implications for lipid peroxidation and detoxification pathways"*
**作者**：Kelson, T.L. et al.
**摘要**：通过ALDH3A2抗体标记，发现该酶在肝脏、皮肤及肠道中高表达，提示其在细胞抗氧化和脂质代谢中的广泛作用。
(注：以上文献信息为示例性内容，实际引用需核实真实文献。)
ALDH3A2 (aldehyde dehydrogenase 3 family member A2) is a key enzyme involved in lipid metabolism, specifically catalyzing the oxidation of long-chain aliphatic aldehydes to their corresponding carboxylic acids. This detoxification process is critical for maintaining cellular homeostasis by preventing the accumulation of toxic lipid peroxidation products. ALDH3A2 is primarily expressed in the endoplasmic reticulum of various tissues, including the liver, skin, and kidneys. Mutations in the ALDH3A2 gene are linked to Sjögren-Larsson syndrome (SLS), a rare autosomal recessive disorder characterized by ichthyosis, intellectual disability, and spastic paraplegia, underscoring the enzyme's vital role in cellular health.
Antibodies targeting ALDH3A2 are essential tools for studying its expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein levels in disease models, particularly SLS and other conditions associated with lipid metabolism dysregulation. Researchers also employ these antibodies to explore ALDH3A2's potential involvement in cancer, as altered expression has been observed in certain tumors. Commercially available ALDH3A2 antibodies are typically developed in hosts such as rabbits or mice, with validation steps including knockout cell line controls to ensure specificity. Their applications extend to diagnostic workflows, aiding in the confirmation of SLS and advancing therapeutic research targeting ALDH3A2-related pathways.
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