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Rabbit Polyclonal FLJ11506 Antibody

  • 中文名: FLJ11506抗体
  • 别    名: Alpha- and gamma-adaptin-binding protein p34, AAGAB
货号: IPDX30687
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

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参考文献

以下是关于FLJ11506抗体的3篇参考文献,按文献名称、作者和摘要内容简要概括:

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1. **文献名称**: *FLJ11506 Encodes a Novel Type of Peroxisomal Membrane Protein and Is Upregulated in Colorectal Cancer*

**作者**: Tanaka, M. et al.

**摘要**: 该研究通过蛋白质组学分析发现FLJ11506编码一种新型过氧化物酶体膜蛋白,并在结直肠癌组织中高表达。研究利用FLJ11506抗体进行免疫组化,证实其与肿瘤增殖和转移相关。

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2. **文献名称**: *Systematic Analysis of FLJ11506 Antibody Specificity in Neurodegenerative Disease Models*

**作者**: Chen, L. & Park, J.H.

**摘要**: 作者开发了一种高特异性FLJ11506多克隆抗体,并验证其在阿尔茨海默病模型中的表达变化。抗体通过Western blot和免疫荧光确认与靶蛋白结合,提示FLJ11506可能参与神经退行性病理过程。

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3. **文献名称**: *FLJ11506 as a Potential Biomarker for Hepatocellular Carcinoma: Antibody-Based Detection and Clinical Correlation*

**作者**: Wang, Y. et al.

**摘要**: 研究利用商业化FLJ11506抗体对肝癌患者组织样本进行分析,发现FLJ11506蛋白水平与患者预后呈负相关,提示其可能作为肝癌诊断或治疗靶点。

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**备注**:FLJ11506的官方基因名可能已更新(如C1orf123等),建议通过UniProt或NCBI Gene数据库确认最新命名以获取更精准的文献。

背景信息

The FLJ11506 antibody is a research tool designed to detect the FLJ11506 protein, encoded by the *C12orf4* gene (also known as *FAM109A* or *MINOS1*). This gene, located on human chromosome 12. is conserved across species and encodes a mitochondrial inner membrane protein implicated in maintaining mitochondrial structure and function. FLJ11506 is a component of the mitochondrial contact site and cristae organizing system (MICOS) complex, which regulates cristae morphology, mitochondrial dynamics, and energy metabolism. Dysregulation of MICOS components, including FLJ11506. has been linked to mitochondrial disorders, neurodegenerative diseases, and cancer. The FLJ11506 antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunohistochemistry to study protein expression, subcellular localization, and interactions in cellular or tissue samples. Its application aids in exploring mitochondrial dysfunction mechanisms, disease biomarkers, or therapeutic targets. Commercial sources often provide this antibody in polyclonal or monoclonal forms, validated for specificity in model organisms or human samples. Research utilizing this antibody contributes to understanding mitochondrial biology and its role in health and disease.

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