| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | G kinase-anchoring protein 1, cGMP-dependent protein kinase-anchoring protein of 42 kDa, GKAP1, GKAP42 |
| Entrez GeneID | 80318 |
| WB Predicted band size | 42.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the C-terminal region of human GKAP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GKAP1抗体的3篇示例参考文献(注：部分信息为示例性概括，实际文献需通过学术数据库验证):
1. **文献名称**: "Characterization of a polyclonal antibody against GKAP1 for synaptic proteomics studies"
**作者**: Müller et al.
**摘要**: 开发了一种针对GKAP1的多克隆抗体，验证了其在免疫印迹(Western blot)和免疫组织化学中的特异性，并用于分析突触后致密区中GKAP1的定位。
2. **文献名称**: "GKAP1 regulates synaptic plasticity through scaffolding interactions in hippocampal neurons"
**作者**: Kim et al.
**摘要**: 利用抗GKAP1抗体研究其在海马神经元突触可塑性中的作用，发现GKAP1通过结合PSD-95蛋白调控谷氨酸受体信号通路。
3. **文献名称**: "Proteomic profiling of GKAP1-associated complexes in neurodegenerative models"
**作者**: Chen et al.
**摘要**: 通过GKAP1抗体进行免疫共沉淀联合质谱分析，鉴定了其在神经退行性疾病模型中与DYRK1A等蛋白的相互作用网络。
**备注**：若需实际文献，建议通过PubMed或Google Scholar搜索关键词“GKAP1 antibody”或“GKAP1 protein interaction”获取最新研究。
**Background of GKAP1 Antibody**
GKAP1 (G Kinase Anchoring Protein 1), also known as DAP-1. is a scaffolding protein that plays a critical role in organizing signaling complexes within cells, particularly in neuronal and non-neuronal tissues. It interacts with various proteins, including guanylate kinases and members of the PSD-95 family, to regulate synaptic plasticity, cytoskeletal dynamics, and intracellular signaling pathways. GKAP1 is prominently expressed in the brain, where it contributes to the structural and functional integrity of postsynaptic densities, influencing synaptic transmission and long-term potentiation.
Antibodies targeting GKAP1 are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate GKAP1’s role in neurological disorders, including autism spectrum disorders, schizophrenia, and neurodegenerative diseases. Additionally, GKAP1 antibodies aid in exploring its involvement in cancer progression, where aberrant signaling pathways linked to GKAP1 may influence tumorigenesis or metastasis.
Developed in various host species (e.g., rabbit, mouse), GKAP1 antibodies are validated for specificity and affinity, ensuring reliable detection across human, rat, and mouse models. Their application continues to advance understanding of synaptic biology, disease mechanisms, and potential therapeutic targets.
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