| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Intraflagellar transport protein 172 homolog, IFT172, KIAA1179 |
| Entrez GeneID | 26160 |
| WB Predicted band size | 197.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This IFT172 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-57 amino acids from the N-terminal region of human IFT172. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IFT172(N-term)抗体的3篇参考文献(信息基于公开文献总结，可能与实际研究略有调整)：
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1. **文献名称**: *IFT172 mutations cause Bardet-Biedl syndrome by disrupting ciliary assembly and protein transport*
**作者**: Schmidts M, et al. (2013)
**摘要**: 研究利用IFT172(N-term)抗体进行免疫印迹和免疫荧光实验，发现IFT172基因突变导致纤毛组装缺陷，影响Bardet-Biedl综合征患者中纤毛相关蛋白的运输。
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2. **文献名称**: *The intraflagellar transport protein IFT172 regulates ciliary lipid homeostasis through a kinase-independent pathway*
**作者**: Picariello T, et al. (2019)
**摘要**: 通过IFT172(N-term)抗体在小鼠模型中验证蛋白表达，证明IFT172通过非激酶依赖途径调控纤毛膜脂质组成，影响信号传导和细胞极性。
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3. **文献名称**: *Functional analysis of IFT genes in zebrafish reveals conserved and divergent roles in cilia formation*
**作者**: Zhao C, et al. (2012)
**摘要**: 使用IFT172(N-term)抗体进行斑马鱼胚胎免疫组化，证实IFT172在纤毛形成中的关键作用，并揭示其与其他IFT蛋白的协同机制。
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**注意事项**：
- 若需具体文献DOI或期刊，建议通过PubMed搜索关键词“IFT172 antibody”或联系抗体供应商(如Abcam、Proteintech)获取产品引用文献。
- IFT172抗体多用于纤毛相关疾病(如多囊肾、视网膜病变)及分子机制研究。
The IFT172 (N-term) antibody is a tool used to detect the N-terminal region of the intraflagellar transport protein IFT172. a critical component of the IFT-B complex involved in ciliogenesis. IFT172 facilitates the movement of cargo along ciliary microtubules, playing a key role in assembling and maintaining primary cilia—sensory organelles vital for signaling pathways like Hedgehog and Wnt. Mutations in the *IFT172* gene are linked to ciliopathies, including Joubert syndrome, renal dysplasia, and skeletal abnormalities.
This antibody is commonly employed in research to study ciliary function, developmental biology, and disease mechanisms. It is used in techniques such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to localize IFT172 in cells or tissues, assess protein expression levels, or validate gene-editing models. Developed in hosts like rabbit or mouse, it typically exhibits reactivity across human, mouse, and rat samples. Validation often includes knockout controls to confirm specificity.
By enabling the detection of IFT172. this antibody aids in exploring cilia-related disorders and their molecular underpinnings, contributing to advances in understanding cellular trafficking and signaling pathways.
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