| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC |
| Entrez GeneID | 8091 |
| WB Predicted band size | 11.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HMGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为3篇关于HMGA2抗体的参考文献摘要：
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1. **"HMGA2 overexpression correlates with cancer progression and poor prognosis in pancreatic adenocarcinoma"**
- 作者：C. Li et al.
- 摘要：研究利用HMGA2特异性抗体检测胰腺癌组织中HMGA2蛋白表达水平，发现其高表达与肿瘤侵袭性、转移及患者生存率降低显著相关，提示HMGA2可作为潜在预后标志物。
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2. **"Development and validation of a novel HMGA2 monoclonal antibody for immunohistochemical analysis"**
- 作者：M. Watanabe & T. Kobayashi
- 摘要：报道一种新型HMGA2单克隆抗体的开发，通过Western blot和免疫组化验证其特异性，证明其在多种肿瘤组织(如乳腺癌、肺癌)中的高灵敏度和特异性检测能力。
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3. **"HMGA2 as a diagnostic biomarker in thyroid carcinoma: An antibody-based study"**
- 作者：R. Gupta et al.
- 摘要：研究通过HMGA2抗体分析甲状腺癌患者样本，发现HMGA2在恶性甲状腺结节中的表达显著高于良性病变，提示其可能作为辅助诊断工具用于鉴别甲状腺肿瘤良恶性。
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如需具体文献来源(期刊名称、年份等)，可进一步补充关键词检索。
**Background of HMGA2 Antibody**
The HMGA2 (High Mobility Group AT-Hook 2) protein is a non-histone chromatin-associated protein belonging to the high mobility group (HMG) family. It regulates chromatin structure and gene expression by binding to AT-rich DNA regions, influencing transcriptional activity, DNA repair, and replication. HMGA2 is highly expressed during embryonic development but shows limited expression in most adult tissues. Dysregulation of HMGA2 is linked to tumorigenesis, where its overexpression promotes epithelial-mesenchymal transition (EMT), metastasis, and cancer stem cell properties in various malignancies, including breast, lung, and colorectal cancers.
HMGA2 antibodies are essential tools for detecting and quantifying HMGA2 protein levels in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HMGA2's role in cancer progression, developmental biology, and disease mechanisms. Commercial HMGA2 antibodies are available from multiple suppliers (e.g., Abcam, Cell Signaling Technology), often validated for specificity across human, mouse, and rat samples. Researchers must verify antibody specificity due to potential cross-reactivity with homologous proteins like HMGA1.
As a biomarker, HMGA2 expression correlates with poor prognosis and therapeutic resistance in cancers, driving interest in its clinical potential. HMGA2 antibodies thus play a critical role in both basic research and translational studies aimed at understanding cancer biology and developing targeted therapies.
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