| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1, TBKBP1 {ECO:0000312|EMBL:AAI114191} |
| Entrez GeneID | 9755 |
| WB Predicted band size | 67.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TBKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TBKB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBK1 (N-term)抗体的3篇文献及其摘要的简要概括：
1. **文献名称**：*"TBK1 is a key regulator of RIG-I signaling and controls antiviral immune responses"*
**作者**：S. Sharma et al.
**摘要**：该研究使用N端特异性TBK1抗体(货号：某品牌)，通过免疫沉淀和Western blot验证TBK1在抗病毒天然免疫中的作用，发现TBK1通过磷酸化IRF3调控干扰素信号通路。
2. **文献名称**：*"Autophagy-dependent phosphorylation of TBK1 by ULK1 promotes innate immunity"*
**作者**：J. Kim et al.
**摘要**：研究通过N端TBK1抗体检测自噬过程中TBK1的磷酸化状态，发现ULK1介导的TBK1活化对清除胞内病原体至关重要，揭示了自噬与免疫信号间的联系。
3. **文献名称**：*"Structural basis for TBK1 activation by autophagy receptors"*
**作者**：M. Tu et al.
**摘要**：利用TBK1 (N-term)抗体进行免疫荧光定位，结合结构生物学分析，阐明自噬受体OPTN通过结合TBK1的N端结构域激活其激酶活性，促进炎症反应。
**注**：以上文献为示例性概括，实际引用时需根据具体研究补充真实文献信息(如DOI或期刊名称)。建议通过PubMed或Google Scholar以“TBK1 antibody N-terminal”为关键词检索最新研究。
The TBK1 (N-term) antibody is a tool used to detect TANK-binding kinase 1 (TBK1), a serine/threonine kinase critical in innate immune signaling and inflammatory pathways. TBK1 plays a central role in regulating type I interferon (IFN) responses by phosphorylating transcription factors like IRF3/IRF7. which drive IFN production during viral infections or cellular stress. It also participates in NF-κB activation, autophagy, and cellular homeostasis. The N-terminal region of TBK1 contains key domains for protein-protein interactions, including dimerization and recruitment to signaling complexes (e.g., STING, MAVS).
This antibody specifically targets the N-terminal region of TBK1. enabling researchers to study its expression, localization, and activation status in various contexts, such as viral infection, autoimmune diseases, or cancer. It is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Validation often includes testing in TBK1-knockout models to confirm specificity. Dysregulation of TBK1 is linked to disorders like lupus, rheumatoid arthritis, and certain cancers, making this antibody valuable for mechanistic and therapeutic studies. Commercial versions are typically raised in rabbits or mice, with reactivity across human, mouse, and rat samples. Its application aids in exploring TBK1’s dual roles in immunity and pathology, as well as drug development targeting TBK1-related pathways.
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