| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane protein 79, Mattrin, TMEM79, MATT |
| Entrez GeneID | 84283 |
| WB Predicted band size | 43.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TMM79 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-391 amino acids from the C-terminal region of human TMM79. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于学术文献结构的模拟示例(注：TMM79相关研究可能较为特定，实际文献需根据具体基因/蛋白名称核实)：
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1. **文献名称**: *TMM79 regulates mitochondrial membrane transport in apoptosis*
**作者**: Smith J, et al.
**摘要**: 本研究通过C端抗体验证了TMM79蛋白在线粒体外膜的表达，证实其通过调控离子通道参与细胞凋亡通路，Western blot及免疫荧光显示敲低TMM79可抑制caspase活化。
2. **文献名称**: *Characterization of TMM79-C terminal antibody specificity in neurodegenerative models*
**作者**: Lee H, et al.
**摘要**: 文章报道了一种高特异性TMM79 C端多克隆抗体的开发，应用于阿尔茨海默病模型小鼠脑组织，证明TMM79与tau蛋白异常磷酸化存在共定位。
3. **文献名称**: *TMM79 interacts with ER stress sensors: Evidence from co-immunoprecipitation assays*
**作者**: Garcia R, et al.
**摘要**: 利用TMM79 C端抗体进行免疫共沉淀实验，发现其与IRE1α在内质网应激中的相互作用，提示TMM79可能参与未折叠蛋白反应调控。
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**注意**：以上为模拟示例，实际研究中需根据具体基因名称(如确认是否为**TMEM79**等相似命名)检索PubMed等数据库。建议核实目标蛋白标准命名或提供更多背景信息以便精准查找。
The TMM79 (C-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the C-terminal region of the Transmembrane Protein 79 (TMM79), a protein encoded by the TMEM79 gene in humans. TMM79 is a membrane-associated protein implicated in skin barrier function and homeostasis. Studies suggest it interacts with filaggrin and other structural proteins to maintain epidermal integrity, with mutations linked to atopic dermatitis and ichthyosis. The C-terminal domain is critical for its intracellular trafficking and functional interactions.
This antibody is widely used in research to detect TMM79 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the study of skin disorders and protein localization. Its specificity for the C-terminus ensures recognition of full-length or truncated forms, helping differentiate between wild-type and mutant variants. Developed in hosts like rabbits or mice, it is validated for reactivity in human and possibly rodent tissues, depending on immunogen conservation.
Research utilizing the TMM79 (C-term) antibody has advanced understanding of epidermal protein networks and their role in inflammatory skin diseases, offering potential insights into therapeutic targets. Proper controls, such as knockout validation, are essential to confirm signal specificity in experimental models.
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