首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal SCRN1(N-term) Antibody

  • 中文名： SCRN1 (N-term)抗体
  • 别    名： Secernin-1, SCRN1, KIAA0193
货号: IPDX30660
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSecernin-1, SCRN1, KIAA0193
Entrez GeneID9805
WB Predicted band size46.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SCRN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from the N-terminal region of human SCRN1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于SCRN1(N-term)抗体的文献示例(内容基于公开研究整理，部分信息为示例性概括)：

---

1. **文献名称**: *SCRN1 modulates secretory granule maturation in neuroendocrine cells*

**作者**: Yamamoto A, et al.

**摘要**: 本研究通过使用SCRN1 N端抗体进行免疫印迹和免疫荧光实验，发现SCRN1通过与囊泡运输相关蛋白相互作用，调控神经内分泌细胞中分泌颗粒的成熟过程。研究揭示了其在胞吐作用中的关键作用。

2. **文献名称**: *Expression profiling of SCRN1 in colorectal cancer and its clinical implications*

**作者**: Chen L, et al.

**摘要**: 利用SCRN1 N端抗体检测结直肠癌组织中的蛋白表达水平，发现SCRN1高表达与患者预后不良相关。机制研究表明其通过调节MAPK信号通路促进肿瘤侵袭。

3. **文献名称**: *SCRN1 interacts with autophagy machinery to regulate lysosomal function*

**作者**: Tanaka K, et al.

**摘要**: 通过N端抗体进行免疫共沉淀和亚细胞定位分析，证明SCRN1与自噬相关蛋白LC3结合，参与溶酶体功能调控，影响细胞内代谢稳态。研究为神经退行性疾病提供了潜在治疗靶点。

4. **文献名称**: *Developmental regulation of SCRN1 in mouse brain*

**作者**: Smith J, et al.

**摘要**: 使用SCRN1 N端抗体对小鼠脑组织进行免疫组化分析，发现SCRN1在胚胎发育期高表达于海马区，提示其可能参与神经元突触形成和可塑性调节。

---

**备注**：以上文献为示例性内容，实际引用时建议通过PubMed或Web of Science核对具体信息。若需真实文献，可检索关键词“SCRN1 antibody N-terminal”或结合实验场景(如Western blot、IHC)筛选。

背景信息

The SCRN1 (N-term) antibody is a tool designed to detect the N-terminal region of Secernin-1 (SCRN1), a protein implicated in intracellular signaling and vesicular trafficking. SCRN1 belongs to the secernin family, which shares homology with proteins involved in secretory pathways. It is ubiquitously expressed but shows higher abundance in secretory cells, suggesting roles in exocytosis, membrane dynamics, or immune response modulation. Studies link SCRN1 to actin cytoskeleton regulation and neurosecretory processes, though its precise molecular mechanisms remain under investigation. The N-terminal domain is critical for SCRN1’s function, potentially mediating protein-protein interactions or subcellular localization. Researchers employ SCRN1 (N-term) antibodies primarily in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study expression patterns, tissue distribution, and disease associations. Aberrant SCRN1 expression has been observed in certain cancers and neurological disorders, hinting at its diagnostic or therapeutic relevance. However, functional studies are still limited, and antibody specificity validation (e.g., via knockout controls) is essential for accurate interpretation. Overall, this antibody serves as a key reagent for unraveling SCRN1’s biological roles in cellular homeostasis and pathology.

客户数据及评论

折叠内容

大包装询价

×