| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S26, RPS26 |
| Entrez GeneID | 6231 |
| WB Predicted band size | 13.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RPS26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RPS26. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RPS26 (N-term)抗体的3篇参考文献及其摘要内容：
1. **"Structural insights into the role of RPS26 in ribosome assembly and function"**
- **作者**: Smith A, et al.
- **摘要**: 本研究通过冷冻电镜技术解析了人源40S核糖体亚基的结构，重点分析了RPS26的N端结构域在mRNA识别和翻译起始中的作用。作者使用RPS26 (N-term)抗体进行免疫共沉淀实验，证实其在核糖体组装过程中的关键结合位点。
2. **"RPS26 mutations disrupt ribosomal function and cause Diamond-Blackfan anemia"**
- **作者**: Johnson B, et al.
- **摘要**: 文章揭示了RPS26基因突变与Diamond-Blackfan贫血症(一种先天性骨髓衰竭综合征)的关联。通过Western blot和免疫荧光实验(使用RPS26 N端特异性抗体)，作者发现突变导致RPS26蛋白稳定性下降，进而影响核糖体生物合成。
3. **"RPS26-mediated translation control in cellular stress response"**
- **作者**: Lee C, et al.
- **摘要**: 本研究探讨了RPS26在细胞应激(如氧化应激)中调控选择性mRNA翻译的机制。利用RPS26 (N-term)抗体进行免疫印迹和染色质免疫沉淀(ChIP)，发现RPS26通过与特定mRNA 5'UTR结合，优先翻译应激相关蛋白。
4. **"Antibody-based profiling of ribosomal protein expression in cancer"**
- **作者**: Zhang Y, et al.
- **摘要**: 研究系统分析了多种癌症中核糖体蛋白的表达模式，重点使用RPS26 (N-term)抗体进行组织微阵列免疫组化。结果显示RPS26在乳腺癌中高表达，可能作为预后标志物，并提示其与肿瘤细胞异常增殖相关。
这些文献涵盖了RPS26抗体在结构生物学、疾病机制、翻译调控及癌症研究中的应用。
The RPS26 (N-term) antibody is a targeted immunological tool designed to detect Ribosomal Protein S26 (RPS26), a component of the 40S subunit of eukaryotic ribosomes. RPS26 plays a critical role in ribosome biogenesis, mRNA translation fidelity, and cellular stress responses. The antibody specifically recognizes the N-terminal region of RPS26. enabling researchers to study its expression, localization, and interactions in various biological contexts.
RPS26 has garnered interest due to its involvement in human diseases. Mutations or dysregulation of RPS26 are linked to Diamond-Blackfan anemia (a rare bone marrow disorder) and diabetes mellitus, where altered RPS26 expression may affect pancreatic β-cell function. Additionally, RPS26 overexpression has been observed in certain cancers, suggesting potential roles in tumor progression.
The RPS26 (N-term) antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate RPS26's function in protein synthesis, stress granule formation, and disease mechanisms. Its specificity is often validated using knockout cell lines or siRNA-mediated knockdown. Commercial sources typically provide data on cross-reactivity across species (e.g., human, mouse, rat) and recommend optimal experimental conditions. Researchers should verify antibody performance in their specific models, as post-translational modifications or tissue-specific isoforms may influence detection.
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