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Rabbit Polyclonal LHPL2 Antibody

  • 中文名: LHPL2抗体
  • 别    名: Lipoma HMGIC fusion partner-like 2 protein, LHFPL2, KIAA0206
货号: IPDX30656
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human, Hamster
IF 咨询技术 Human, Hamster
IHC 咨询技术 Human, Hamster
ICC 技术咨询 Human, Hamster
FCM 咨询技术 Human, Hamster
Elisa 咨询技术 Human, Hamster

产品详情

AliasesLipoma HMGIC fusion partner-like 2 protein, LHFPL2, KIAA0206
Entrez GeneID10184
WB Predicted band size24.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Hamster
ImmunogenThis LHPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-223 amino acids from the C-terminal region of human LHPL2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于LHPL2抗体的假设性参考文献示例(注:LHPL2抗体相关文献可能较少或为虚构名称,建议核实具体名称或扩展关键词):

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1. **文献名称**: "LHPL2 Antibody Development for Targeted Cancer Therapy"

**作者**: Smith J, et al.

**摘要**: 本研究开发了一种针对LHPL2蛋白的单克隆抗体,验证了其在多种癌细胞系中的特异性结合能力,并探讨了其作为靶向治疗工具的潜力。

2. **文献名称**: "LHPL2 Expression Profiling in Neural Tissues Using a Novel Polyclonal Antibody"

**作者**: Zhang Y, et al.

**摘要**: 通过制备兔源多克隆抗体,分析了LHPL2蛋白在小鼠脑组织中的分布,发现其在前额叶皮层和海马区高表达,提示其可能与神经发育相关。

3. **文献名称**: "Validation of LHPL2 Antibody for Immunohistochemical Applications"

**作者**: Lee S, et al.

**摘要**: 本研究系统验证了LHPL2抗体在福尔马林固定石蜡包埋组织中的免疫组化适用性,证明其在肝癌和乳腺癌诊断中的临床价值。

4. **文献名称**: "LHPL2 Knockout Model Reveals Antibody Cross-Reactivity Challenges"

**作者**: Brown K, et al.

**摘要**: 利用LHPL2基因敲除小鼠模型,评估了商用抗体的特异性,发现部分抗体存在非特异性结合问题,强调抗体验证的重要性。

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**说明**:上述文献为假设性示例,实际研究中LHPL2可能为虚构或特定项目名称。建议通过PubMed、Google Scholar等平台,结合具体研究目标(如疾病、技术)扩展检索关键词(如“LHPL2 + 抗体 + [疾病/技术]”)。如需求真实文献,可提供更详细背景或修正名称。

背景信息

The LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) antibody is a research tool targeting the LHPP protein, a tumor suppressor implicated in various cancers. Discovered through genomic studies, LHPP encodes a histidine phosphatase enzyme that regulates metabolic pathways by hydrolyzing phosphorylated intermediates. It is ubiquitously expressed but shows reduced levels in malignancies like hepatocellular carcinoma (HCC), gastric cancer, and oral squamous cell carcinoma, correlating with poor prognosis. LHPP's tumor-suppressive role involves modulating energy metabolism, inhibiting cell proliferation, and promoting apoptosis. Antibodies against LHPP are primarily used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess protein expression patterns in tissues or cell lines. Researchers employ these antibodies to investigate LHPP's involvement in cancer progression, metabolic dysregulation, and therapeutic resistance. Recent studies highlight its potential as a diagnostic biomarker or therapeutic target, particularly in cancers linked to metabolic reprogramming. However, functional mechanisms remain under exploration, emphasizing the need for high-specificity LHPP antibodies to advance preclinical and translational studies. Commercial LHPP antibodies are typically validated for cross-reactivity and batch consistency to ensure reproducibility in experimental models.

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