| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HAUS augmin-like complex subunit 4, HAUS4, C14orf94 |
| Entrez GeneID | 54930 |
| WB Predicted band size | 42.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HAUS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the C-terminal region of human HAUS4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是与HAUS4抗体相关的模拟参考文献(仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"The HAUS complex is a key regulator of non-centrosomal microtubule organization during spindle assembly"*
**作者**: Gassmann, R. et al.
**摘要**: 本研究阐明了HAUS复合体(含HAUS4亚基)在纺锤体微管锚定中的作用，通过RNAi敲低HAUS4并利用特异性抗体进行免疫荧光染色，发现其缺失导致纺锤体异常和染色体排列错误，提示HAUS4对细胞分裂至关重要。
2. **文献名称**: *"HAUS4 overexpression promotes tumor progression via modulating mitotic kinases in breast cancer"*
**作者**: Smith, J.D. et al.
**摘要**: 该研究通过HAUS4抗体进行Western blot和免疫组化分析，发现HAUS4在乳腺癌组织中高表达，并与其促进有丝分裂激酶活性和肿瘤转移相关，为癌症治疗提供了潜在靶点。
3. **文献名称**: *"Functional characterization of HAUS complex subunits in human cells"*
**作者**: Lawo, S. et al.
**摘要**: 利用HAUS4抗体进行蛋白质互作分析，证实HAUS4与其他亚基形成复合体维持微管稳定性。CRISPR敲除HAUS4后，细胞显示微管网络紊乱，证明其是HAUS复合体功能的核心组分。
4. **文献名称**: *"A genome-wide siRNA screen identifies HAUS4 as a critical factor for centriole duplication"*
**作者**: Tang, C.J. et al.
**摘要**: 通过全基因组筛选结合HAUS4抗体的免疫印迹验证，发现HAUS4缺失导致中心体复制缺陷，揭示其在细胞周期调控中的新机制。
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**注意**：以上内容为模拟生成，实际文献需通过PubMed、Google Scholar等平台检索确认。建议使用关键词“HAUS4 antibody”或“HAUS complex”查找最新研究。
The HAUS4 antibody is a tool used to detect HAUS4. a subunit of the HAUS (HAUS Augmin-like complex) protein complex, which plays a critical role in mitotic spindle assembly and microtubule dynamics. The HAUS complex, composed of eight subunits (HAUS1-HAUS8), is essential for anchoring microtubules to the mitotic spindle during cell division, ensuring proper chromosome segregation. HAUS4 (also known as DGT4) contributes to the structural integrity of the complex and facilitates interactions with other mitotic regulators, such as the γ-tubulin ring complex (γ-TuRC), to promote microtubule nucleation.
Research involving HAUS4 antibodies often focuses on understanding spindle formation, cell cycle regulation, and genome stability. These antibodies are utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess HAUS4 expression levels, subcellular localization, and interactions in various biological contexts. Dysregulation of HAUS4 has been linked to mitotic errors, chromosomal instability, and diseases such as cancer, making it a potential biomarker or therapeutic target.
HAUS4 antibodies are critical for elucidating the molecular mechanisms of mitosis and exploring connections between spindle defects and pathological conditions. Their application spans basic cell biology research, cancer studies, and investigations into developmental disorders tied to cell division abnormalities.
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