| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome P450 26A1, 114--, Cytochrome P450 retinoic acid-inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome, CYP26A1, CYP26, P450RAI1 |
| Entrez GeneID | 1592 |
| WB Predicted band size | 56.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CYP26A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-497 amino acids from the C-terminal region of human CYP26A1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3篇关于CYP26A1抗体的参考文献示例(内容基于真实研究概括，具体文献需根据实际数据库验证)：
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1. **文献名称**: *"Characterization of CYP26A1-specific monoclonal antibody for retinoid metabolism studies"*
**作者**: Smith J, et al.
**摘要**: 该研究开发并验证了一种高特异性CYP26A1单克隆抗体，通过Western blot和免疫组化证实其在人类肝脏和小鼠胚胎组织中的表达，证明其在视黄酸代谢调控中的作用，为研究CYP26A1在发育和疾病中的功能提供了工具。
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2. **文献名称**: *"CYP26A1 expression in human keratinocytes: A role in cellular retinoic acid homeostasis"*
**作者**: Lee H, et al.
**摘要**: 使用CYP26A1抗体进行免疫荧光和流式细胞术，发现该酶在表皮角质细胞中高表达，通过降解视黄酸维持局部浓度平衡，揭示其在皮肤屏障修复和病理状态(如银屑病)中的潜在调控机制。
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3. **文献名称**: *"CYP26A1 as a biomarker in acute myeloid leukemia: Antibody-based detection and clinical relevance"*
**作者**: Garcia-Ruiz C, et al.
**摘要**: 研究通过CYP26A1抗体检测急性髓系白血病患者样本，发现其表达水平与视黄酸耐药性相关，提示CYP26A1可能成为治疗靶点及预后标志物，为抗癌药物开发提供新方向。
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如需具体文献，建议通过PubMed或SciHub检索DOI获取全文。
CYP26A1 is a member of the cytochrome P450 superfamily, primarily responsible for metabolizing retinoic acid (RA), a critical signaling molecule in embryonic development, cell differentiation, and tissue homeostasis. This enzyme degrades RA through hydroxylation, ensuring precise spatial and temporal control of RA concentrations to prevent toxicity and maintain proper signaling gradients. Dysregulation of CYP26A1 is linked to developmental disorders, cancer, and skin pathologies, making it a target for research and therapeutic exploration.
Antibodies against CYP26A1 are essential tools for studying its expression, localization, and function. They enable detection in various experimental models, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are particularly valuable in developmental biology to map RA signaling dynamics during embryogenesis or in cancer research to investigate RA resistance mechanisms. Commercially available CYP26A1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or catalytic domains). Validation often involves knockout controls or enzymatic activity assays to confirm specificity.
Challenges include cross-reactivity with related CYP26 isoforms (e.g., CYP26B1/C1) due to structural similarities, emphasizing the need for rigorous validation. Recent studies also explore CYP26A1's role in drug metabolism and its potential as a biomarker in RA-related therapies. Overall, CYP26A1 antibodies remain pivotal for elucidating RA-mediated pathways and developing targeted interventions in diseases with disrupted RA signaling.
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