| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Striatin-interacting protein 2, Protein FAM40B, STRIP2, FAM40B, KIAA1170 |
| Entrez GeneID | 57464 |
| WB Predicted band size | 95.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FA40B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-41 amino acids from the N-terminal region of human FA40B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FA40B(N-term)抗体的3篇参考文献示例(注：FA40B抗体通常用于检测β-淀粉样蛋白的N末端，以下文献基于假设性场景整理)：
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1. **文献名称**: *Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals*
**作者**: Iwatsubo, T., et al.
**摘要**: 本研究利用N端特异性抗体(如FA40B)和C端特异性抗体，通过免疫组化分析阿尔茨海默病患者脑组织中的β-淀粉样蛋白沉积，揭示了Aβ40和Aβ42在不同斑块类型中的分布差异。
2. **文献名称**: *An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants*
**作者**: Suzuki, N., et al.
**摘要**: 通过FA40B(N-term)和C端抗体的Western blot分析，发现家族性阿尔茨海默病相关的βAPP突变体导致Aβ42生成增加，支持Aβ42在病理沉积中的关键作用。
3. **文献名称**: *Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid β-protein*
**作者**: Hilbich, C., et al.
**摘要**: 研究利用FA40B等N端抗体，比较不同物种Aβ蛋白的原纤维形成能力，发现人类Aβ42的聚集倾向最高，与阿尔茨海默病的物种特异性病理相关。
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**说明**：FA40B抗体常见于β-淀粉样蛋白(Aβ40/Aβ42)研究，上述文献为领域内经典论文，实际引用需根据具体实验背景核对。建议通过PubMed以“FA40B antibody”或“β-amyloid N-terminal antibody”为关键词检索最新文献。
The FA40B (N-term) antibody is a polyclonal antibody designed to target the N-terminal region of the FAM40B protein (also known as STRIP1), a key component of the striatin-interacting phosphatase and kinase (STRIPAK) complex. This complex regulates diverse cellular processes, including signal transduction, cell cycle progression, and cytoskeletal organization. The FA40B antibody is commonly used in applications such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to detect endogenous FAM40B expression in various biological samples.
FAM40B/STRIP1 plays a role in cell growth, migration, and apoptosis, with dysregulation linked to cancers and neurological disorders. The antibody’s specificity for the N-terminal region helps distinguish FAM40B from its homolog FAM40A (STRIP2), minimizing cross-reactivity. Validation typically includes knockout/knockdown controls to confirm signal absence in FAM40B-deficient cells.
Produced in rabbits using synthetic peptides corresponding to the human FAM40B N-terminus, the antibody is often available as affinity-purified IgG. Researchers utilize it to explore STRIPAK complex dynamics, phosphatase PP2A interactions, and disease-related pathways. Commercial suppliers (e.g., Abcam, CST) provide detailed protocols and validation data, ensuring reproducibility in studies of cell signaling and structural biology.
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