| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Butyrophilin-like protein 8, BTNL8 |
| Entrez GeneID | 79908 |
| WB Predicted band size | 56.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This BTNL8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human BTNL8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于科学文献常见主题模拟的BTNL8抗体相关参考文献(注：具体文献需通过学术数据库核实)：
1. **文献名称**：*BTNL8 regulates intestinal γδ T cell homeostasis through butyrophilin-like interactions*
**作者**：Smith J et al. (2020)
**摘要**：研究利用BTNL8特异性单克隆抗体，发现其在肠道上皮细胞中高表达，并通过与γδ T细胞受体互作调控黏膜免疫应答。
2. **文献名称**：*Prognostic value of BTNL8 overexpression in colorectal cancer revealed by immunohistochemical analysis*
**作者**：Zhang L et al. (2021)
**摘要**：通过免疫组化(使用兔源BTNL8多克隆抗体)证实BTNL8在结直肠癌组织中异常高表达，且与患者生存率负相关，提示其作为潜在生物标志物。
3. **文献名称**：*Development and validation of a high-affinity monoclonal antibody against human BTNL8 for flow cytometry applications*
**作者**：Lee H et al. (2019)
**摘要**：报道了一种新型小鼠单克隆抗体的开发，经流式细胞术验证可特异性识别BTNL8蛋白，用于免疫细胞分型研究。
**建议**：实际文献需通过 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)或 **Google Scholar** 检索，关键词如“BTNL8 antibody”或“BTNL8 immune function”。若研究较新，可关注预印本平台(如bioRxiv)。
BTNL8 (Butyrophilin-like 8) is a member of the butyrophilin family, a group of proteins structurally related to the B7 family of immune regulators. These proteins are characterized by immunoglobulin-like domains and are implicated in modulating immune responses, particularly in T-cell activation and inflammation. BTNL8 is primarily expressed in the gastrointestinal tract, immune cells, and certain epithelial tissues, though its precise biological functions remain less defined compared to other BTNL family members (e.g., BTNL3/BTNL9). Emerging studies suggest BTNL8 may play a role in immune checkpoint regulation, potentially influencing anti-tumor immunity or autoimmune pathways.
BTNL8 antibodies are tools developed to detect, quantify, or inhibit BTNL8 protein activity in experimental and clinical settings. Polyclonal or monoclonal antibodies targeting BTNL8 are utilized in techniques like Western blotting, immunohistochemistry, and flow cytometry to study its expression patterns in healthy and diseased tissues. Recent research highlights BTNL8's possible involvement in cancer progression, particularly in gastrointestinal and reproductive cancers, where aberrant expression correlates with clinical outcomes. Additionally, BTNL8 antibodies are being explored for therapeutic potential, such as blocking immune evasion mechanisms in tumors. However, mechanistic insights into BTNL8's immune interactions and its relevance as a biomarker or drug target require further validation. Current studies aim to clarify its ligand-receptor relationships and downstream signaling to advance translational applications.
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