| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein EFR3 homolog A, Protein EFR3-like, EFR3A, KIAA0143 |
| Entrez GeneID | 23167 |
| WB Predicted band size | 92.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EFR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-664 amino acids from the C-terminal region of human EFR3A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于EFR3A抗体的3篇示例参考文献(注：以下为模拟生成的示例文献，实际文献需通过学术数据库查询)：
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1. **文献名称**: *EFR3A regulates phosphatidylinositol 4-kinase activity and neuronal membrane homeostasis*
**作者**: Smith J, et al.
**摘要**: 研究揭示了EFR3A蛋白通过调控磷脂酰肌醇4-激酶(PI4K)的活性，在维持神经元细胞膜动态平衡中的关键作用，并开发了特异性抗体用于其功能分析。
2. **文献名称**: *EFR3A as a potential biomarker in Alzheimer's disease: Antibody-based detection in cerebrospinal fluid*
**作者**: Lee S, et al.
**摘要**: 通过抗体验证发现，EFR3A在阿尔茨海默病患者脑脊液中表达异常，提示其可能作为神经退行性疾病的生物标志物，为诊断工具开发提供依据。
3. **文献名称**: *Development of a high-affinity monoclonal antibody for EFR3A functional studies*
**作者**: García-Ruiz A, et al.
**摘要**: 报道了一种新型EFR3A单克隆抗体的开发，该抗体成功应用于免疫沉淀和活细胞成像，证实EFR3A与细胞膜修复通路中的蛋白质存在相互作用。
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建议通过PubMed或Google Scholar搜索关键词“EFR3A antibody”、“EFR3A function”或结合具体研究领域(如神经科学、膜生物学)获取真实文献。
The EFR3A antibody targets EFR3 homolog A (EFR3A), a conserved protein involved in phosphatidylinositol metabolism and membrane organization. EFR3A is a key component of the PI4KIIIα complex, which regulates the synthesis of phosphatidylinositol 4-phosphate (PI4P), a lipid critical for membrane trafficking, signaling, and organelle identity. Structurally, EFR3A contains a conserved N-terminal domain that anchors the PI4KIIIα complex to the plasma membrane, facilitating PI4P production. It shares homology with yeast Efr3. a protein essential for lipid kinase activity and membrane homeostasis.
Research on EFR3A has highlighted its role in neuronal development, synaptic function, and cellular polarity. Dysregulation of EFR3A or its associated pathways is implicated in neurological disorders, including Alzheimer’s disease, due to disrupted lipid signaling and vesicle trafficking. Antibodies against EFR3A are widely used in studies to visualize its subcellular localization, assess protein expression levels, or investigate interactions within the PI4KIIIα complex. These tools are critical for elucidating mechanisms of membrane dynamics, neurodevelopment, and disease pathology. Recent studies also explore EFR3A’s potential as a biomarker or therapeutic target in cancers and neurodegeneration. The antibody’s specificity and validation in assays like Western blot, immunofluorescence, and co-immunoprecipitation make it a valuable resource for both basic and translational research.
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