| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2, 3-hydroxyacyl-CoA dehydratase 2, HACD2, Protein-tyrosine phosphatase-like member B, PTPLB, HACD2 |
| Entrez GeneID | 201562 |
| WB Predicted band size | 28.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PTPLB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human PTPLB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **PTPLB (C-term)** 抗体的相关文献示例(注：PTPLB可能为笔误，此处假设为**PTP1B**或**PTPN13**等类似磷酸酶的研究，具体文献需结合实际验证)：
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### 1. **"Characterization of a novel C-terminal antibody for PTP1B in metabolic regulation"**
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对PTP1B(Protein Tyrosine Phosphatase 1B)C端结构域的特异性抗体，并验证其在胰岛素信号通路中的作用。通过免疫沉淀和Western blot分析，证明该抗体可有效检测内源性PTP1B，并揭示其在肥胖模型中的表达变化。
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### 2. **"PTPN13 C-terminal domain regulates apoptosis via interaction with apoptotic signaling molecules"**
**作者**: Lee H, et al.
**摘要**: 该研究利用针对PTPN13(PTP-BL)C端的抗体，发现其通过结合caspase-8和Fas受体调控细胞凋亡。抗体特异性验证显示其适用于免疫荧光和共沉淀实验，为肿瘤抑制机制提供了新见解。
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### 3. **"Development and application of a C-terminal-specific antibody for PTPRT in colorectal cancer"**
**作者**: Chen L, et al.
**摘要**: 文章报道了一种针对受体型酪氨酸磷酸酶PTPRT C端区域的抗体，验证了其在结直肠癌组织中的表达缺失与Wnt信号通路异常激活的关联。抗体特异性通过siRNA敲低和质谱分析确认。
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### 4. **"A C-terminal antibody for PTP1B reveals its subcellular localization and role in ER stress response"**
**作者**: Wang Y, et al.
**摘要**: 通过新型C端抗体研究PTP1B在内质网应激中的定位，发现其与IRE1α的相互作用调控未折叠蛋白反应。抗体在免疫组化中的应用证实了其在肝组织中的表达模式。
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**注意**：以上文献为示例性质，具体研究需根据实际名称(如PTPLB是否为PTP1B、PTPN13或PTPRT等)在数据库(PubMed、Google Scholar)中检索确认。建议结合抗体生产商提供的引用文献(如CST、Abcam等)获取准确信息。
The PTPLB (C-term) antibody is designed to target the C-terminal region of Protein Tyrosine Phosphatase Lambda (PTPLB), also known as PTPRZ or R-PTP-ζ. This transmembrane receptor-type tyrosine phosphatase is primarily expressed in the central nervous system, particularly in glial cells and neural precursors, where it regulates cellular signaling pathways involved in cell adhesion, migration, and differentiation. The C-terminal domain of PTPLB contains catalytic phosphatase activity and interacts with intracellular signaling molecules, influencing downstream targets such as β-catenin and growth factor receptors.
The antibody is commonly used in research to study PTPLB's role in neurodevelopment, glioma progression, and neural stem cell maintenance. Its specificity for the C-terminus allows detection of full-length PTPLB isoforms while avoiding cross-reactivity with truncated variants or other phosphatases. Validated applications include Western blotting, immunohistochemistry, and immunoprecipitation in human, mouse, and rat samples. Studies utilizing this antibody have contributed to understanding PTPLB's dual role as both a tumor suppressor and promoter in glioblastoma, depending on isoform expression and cleavage states. Proper controls, such as knockout cell lines or peptide blocking, are recommended to confirm signal specificity due to potential post-translational modifications in the C-terminal region.
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