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Rabbit Polyclonal KCTD1(C-term) Antibody

  • 中文名: KCTD1 (C-term)抗体
  • 别    名: BTB/POZ domain-containing protein KCTD1, Potassium channel tetramerization domain-containing protein 1, KCTD1, C18orf5
货号: IPDX30611
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBTB/POZ domain-containing protein KCTD1, Potassium channel tetramerization domain-containing protein 1, KCTD1, C18orf5
Entrez GeneID284252
WB Predicted band size29.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis KCTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-244 amino acids from the C-terminal region of human KCTD1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于KCTD1(C-term)抗体的3篇参考文献及其简要摘要:

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1. **"KCTD1 regulates Wnt/β-catenin signaling by modulating the stability of Dishevelled2 in the cytoplasm"**

*Authors: Zhang Y, Liu Y, Xu X.*

摘要:该研究通过使用KCTD1 C端特异性抗体进行免疫共沉淀(Co-IP)和Western blot分析,揭示了KCTD1通过结合Dishevelled2蛋白调控Wnt/β-catenin信号通路的分子机制,表明KCTD1的C端结构对其功能至关重要。

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2. **"The role of KCTD1 in neural crest development and its interaction with AP-2 transcription factors"**

*Authors: Wang L, Chen J, Nie X.*

摘要:研究利用KCTD1 C端抗体进行免疫荧光染色,发现KCTD1在神经嵴细胞中高表达,并通过其C端与AP-2转录因子相互作用,参与胚胎发育过程中的细胞迁移和分化调控。

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3. **"KCTD1 functions as a tumor suppressor in melanoma by targeting c-Jun for degradation"**

*Authors: Li H, Zhou M, Peng C, et al.*

摘要:通过KCTD1 C端抗体验证其在黑色素瘤细胞中的表达下调,研究证明KCTD1通过泛素化降解c-Jun蛋白抑制肿瘤生长,其C端结构域是结合c-Jun并介导降解的关键区域。

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**备注**:以上文献为模拟示例,实际引用需根据具体研究通过PubMed或Google Scholar检索(可尝试关键词:KCTD1 C-terminal antibody、KCTD1 function)。若需真实文献,建议查阅近年分子生物学或癌症研究领域的期刊。

背景信息

The KCTD1 (C-term) antibody is a tool designed to detect the C-terminal region of the potassium channel tetramerization domain-containing 1 (KCTD1) protein, which belongs to the KCTD family. KCTD1 is a cytoplasmic protein involved in regulating transcriptional activity and cellular signaling pathways, notably the Hedgehog and Wnt pathways. It interacts with proteins like BTRC (β-TrCP) and AP-2 transcription factors, influencing processes such as embryonic development, cell proliferation, and differentiation. Dysregulation of KCTD1 has been implicated in developmental disorders and tumorigenesis. The C-terminal-specific antibody allows researchers to study the full-length protein or distinguish between splice variants, making it valuable for techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Its specificity is often validated using knockout controls or siRNA-mediated knockdown to confirm target recognition. Research utilizing this antibody has provided insights into KCTD1's role in craniofacial development, skin homeostasis, and cancer progression. By enabling precise detection, the antibody supports investigations into KCTD1's molecular interactions and its potential as a therapeutic target in diseases linked to signaling pathway aberrations.

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