WB | 1/1000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/100-1/500 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | BTB/POZ domain-containing protein KCTD1, Potassium channel tetramerization domain-containing protein 1, KCTD1, C18orf5 |
Entrez GeneID | 284252 |
WB Predicted band size | 29.4kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | This KCTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-244 amino acids from the C-terminal region of human KCTD1. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KCTD1(C-term)抗体的3篇参考文献及其简要摘要:
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1. **"KCTD1 regulates Wnt/β-catenin signaling by modulating the stability of Dishevelled2 in the cytoplasm"**
*Authors: Zhang Y, Liu Y, Xu X.*
摘要:该研究通过使用KCTD1 C端特异性抗体进行免疫共沉淀(Co-IP)和Western blot分析,揭示了KCTD1通过结合Dishevelled2蛋白调控Wnt/β-catenin信号通路的分子机制,表明KCTD1的C端结构对其功能至关重要。
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2. **"The role of KCTD1 in neural crest development and its interaction with AP-2 transcription factors"**
*Authors: Wang L, Chen J, Nie X.*
摘要:研究利用KCTD1 C端抗体进行免疫荧光染色,发现KCTD1在神经嵴细胞中高表达,并通过其C端与AP-2转录因子相互作用,参与胚胎发育过程中的细胞迁移和分化调控。
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3. **"KCTD1 functions as a tumor suppressor in melanoma by targeting c-Jun for degradation"**
*Authors: Li H, Zhou M, Peng C, et al.*
摘要:通过KCTD1 C端抗体验证其在黑色素瘤细胞中的表达下调,研究证明KCTD1通过泛素化降解c-Jun蛋白抑制肿瘤生长,其C端结构域是结合c-Jun并介导降解的关键区域。
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**备注**:以上文献为模拟示例,实际引用需根据具体研究通过PubMed或Google Scholar检索(可尝试关键词:KCTD1 C-terminal antibody、KCTD1 function)。若需真实文献,建议查阅近年分子生物学或癌症研究领域的期刊。
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