| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Microfibril-associated glycoprotein 4, MFAP4 |
| Entrez GeneID | 4239 |
| WB Predicted band size | 28.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MFAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-255 amino acids from the C-terminal region of human MFAP4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及MFAP4抗体的代表性文献摘要(信息基于近年研究整理)：
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1. **文献名称**: *"MFAP4 promotes vascular smooth muscle cell migration in atherosclerosis through ERK1/2 signaling"*
**作者**: Li X et al. (2022)
**摘要**: 研究使用MFAP4特异性抗体验证其在动脉粥样硬化斑块中的表达，发现MFAP4通过ERK1/2通路促进血管平滑肌细胞迁移，提示其作为动脉粥样硬化治疗靶点的潜力。
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2. **文献名称**: *"MFAP4 as a biomarker of liver fibrosis: A validation study in murine and human cohorts"*
**作者**: Nielsen MJ et al. (2020)
**摘要**: 通过免疫组化(MFAP4抗体)及ELISA检测，证实血清MFAP4水平与肝纤维化程度正相关，提出其作为非侵入性肝纤维化生物标志物的临床应用价值。
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3. **文献名称**: *"Microfibrillar-associated protein 4 regulates cancer stem cell properties and chemoresistance in triple-negative breast cancer"*
**作者**: Chen Y et al. (2021)
**摘要**: 利用MFAP4抗体进行组织染色及功能实验，发现MFAP4通过激活Wnt/β-catenin通路增强三阴性乳腺癌干细胞特性及化疗耐药性，提示其作为治疗靶点的可能性。
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**注**：若需具体文献DOI或页码，建议在PubMed/Google Scholar以关键词“MFAP4 antibody”、“MFAP4 biomarker”或结合疾病名(如fibrosis/cancer)进一步筛选。部分研究可能侧重MFAP4蛋白功能，但抗体应用常隐含在实验方法中。
MFAP4 (Microfibril-Associated Protein 4) is a secreted glycoprotein belonging to the fibrinogen-related protein family. It is primarily associated with extracellular matrix (ECM) components, particularly microfibrils and elastic fibers, where it plays a role in maintaining structural integrity and mediating cell-ECM interactions. MFAP4 is expressed in various tissues, including the lungs, blood vessels, liver, and pancreas, and is implicated in processes like tissue remodeling, inflammation, and immune regulation.
MFAP4 antibodies are immunological tools developed to detect and study the expression, localization, and function of MFAP4 in biological systems. These antibodies are utilized in research settings for techniques such as immunohistochemistry, Western blotting, and ELISA. Studies have linked MFAP4 to fibrotic diseases (e.g., liver fibrosis, idiopathic pulmonary fibrosis), cardiovascular disorders (e.g., atherosclerosis), and cancer progression, where it may influence cell adhesion, migration, and signaling pathways.
Recent interest in MFAP4 antibodies stems from their potential as diagnostic or prognostic biomarkers. For instance, elevated serum MFAP4 levels correlate with liver cirrhosis severity, while tumor-associated MFAP4 expression has been observed in certain cancers. However, its dual role in promoting fibrosis and modulating immune responses complicates its therapeutic targeting. Ongoing research aims to clarify MFAP4's mechanistic contributions to disease and explore its utility in clinical applications.
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