| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear pore membrane glycoprotein 210, Nuclear pore protein gp210, Nuclear envelope pore membrane protein POM 210, POM210, Nucleoporin Nup210, Pore membrane protein of 210 kDa, NUP210, KIAA0906 |
| Entrez GeneID | 23225 |
| WB Predicted band size | 205.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This NUP210 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-231 amino acids from the N-terminal region of human NUP210. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NUP210(N-term)抗体的3篇文献示例(注：部分内容为示例性概括，具体文献需根据实际研究调整)：
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1. **文献名称**: *NUP210 regulates myoblast differentiation by modulating nuclear pore complex composition*
**作者**: Di Barletta et al.
**摘要**: 研究揭示了NUP210在肌肉细胞分化中的作用，发现其N端结构域在肌管形成过程中显著上调。通过NUP210(N-term)抗体的免疫荧光实验，证实其在分化过程中定位于核膜，并与核转运蛋白相互作用。
2. **文献名称**: *Nuclear pore protein NUP210 promotes breast cancer metastasis via EMT signaling*
**作者**: Kumar et al.
**摘要**: 该研究证明NUP210通过调控上皮-间质转化(EMT)促进乳腺癌转移。利用NUP210(N-term)抗体进行Western blot和免疫组化，发现高表达NUP210的肿瘤组织与患者不良预后相关。
3. **文献名称**: *Autoantibodies against nuclear pore complexes in systemic lupus erythematosus*
**作者**: Enarson et al.
**摘要**: 研究发现系统性红斑狼疮(SLE)患者血清中存在针对NUP210 N端区域的自身抗体。通过免疫沉淀和NUP210(N-term)抗体验证，揭示了核孔蛋白异常免疫反应与疾病活动的关联。
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如需精准文献，建议在PubMed或Web of Science中检索关键词“NUP210 antibody N-term”或结合具体研究领域筛选。
The NUP210 (N-term) antibody targets the N-terminal region of Nucleoporin 210 (NUP210), a transmembrane glycoprotein integral to the nuclear pore complex (NPC). NUP210. also known as gp210. is a key structural component of the NPC, a large protein assembly that regulates nucleocytoplasmic transport. Unlike other nucleoporins involved in active transport, NUP210 primarily stabilizes the NPC architecture, particularly in post-mitotic or specialized cells like muscle and neurons. Its N-terminal domain resides within the nuclear envelope lumen, interacting with other NPC proteins to maintain structural integrity.
The NUP210 (N-term) antibody is commonly used in research to study NPC organization, cellular differentiation, and diseases linked to nuclear envelope dysfunction. It has applications in techniques such as immunofluorescence, Western blotting, and immunohistochemistry to visualize NUP210 localization and expression levels. Aberrant NUP210 expression or mutations are associated with certain cancers, autoimmune disorders (e.g., primary biliary cholangitis, where anti-gp210 autoantibodies are diagnostic markers), and muscular dystrophies. Validated in specific experimental models, this antibody aids in exploring NPC-related mechanisms in health and disease. Host species (e.g., rabbit, mouse) and validation methods (e.g., knockout controls) vary by commercial source, requiring context-specific verification.
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