| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arylsulfatase I, ASI, 316-, ARSI |
| Entrez GeneID | 340075 |
| WB Predicted band size | 64.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ARSI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-483 amino acids from the C-terminal region of human ARSI. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 ARSI (C-term) 抗体的参考文献示例(注：以下内容为模拟生成，实际文献需根据数据库检索确认)：
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1. **标题**: "Development of a C-terminal specific monoclonal antibody for human Arylsulfatase I (ARSI) and its application in enzyme activity studies"
**作者**: Smith J, et al. (2016)
**摘要**: 该研究开发了一种针对人ARSI C端表位的单克隆抗体，用于检测重组ARSI蛋白的表达及酶活性。通过Western blot和免疫沉淀验证抗体特异性，并证实其可用于监测ARSI在细胞内的功能调控。
2. **标题**: "Characterization of ARSI in neurodegenerative disorders using a novel polyclonal C-terminal antibody"
**作者**: Lee H, et al. (2018)
**摘要**: 研究者设计了一种兔源多克隆抗体，靶向ARSI的C末端区域，用于分析阿尔茨海默病模型小鼠脑组织中的ARSI表达变化。抗体在免疫组化中表现出高特异性，揭示了ARSI与病理蛋白聚集的潜在关联。
3. **标题**: "Validation of anti-ARSI (C-term) antibody for diagnostic assays in lysosomal storage diseases"
**作者**: Garcia R, et al. (2020)
**摘要**: 研究评估了一种商业化ARSI C端抗体在溶酶体贮积症诊断中的适用性。通过ELISA和免疫荧光实验，证实该抗体能可靠检测患者成纤维细胞中ARSI的缺失或异常表达，支持其作为生物标志物的潜力。
4. **标题**: "Structural insights into ARSI function through C-terminal epitope mapping"
**作者**: Wang Y, et al. (2022)
**摘要**: 利用C端特异性抗体进行表位定位和结构分析，揭示了ARSI C端结构域对其催化活性的调控机制。研究结合X射线晶体学数据，阐明了抗体结合位点与酶功能的关系。
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建议通过PubMed、Google Scholar等平台以关键词 **"ARSI C-terminal antibody"** 或 **"Arylsulfatase I antibody C-term"** 检索真实文献，并核对作者及摘要内容。
The ARSI (C-term) antibody is a polyclonal antibody specifically designed to target the C-terminal region of the Arylsulfatase I (ARSI) protein, a member of the sulfatase enzyme family. ARSI, encoded by the ARSI gene in humans, is a lysosomal enzyme that catalyzes the hydrolysis of sulfate esters, playing a critical role in metabolic pathways involving sulfated molecules such as glycosaminoglycans. This enzyme is implicated in lysosomal storage disorders, particularly metachromatic leukodystrophy (MLD), where sulfatide accumulation leads to neurodegenerative complications.
The C-terminal region of ARSI is crucial for its enzymatic activity and structural stability, making it a key target for functional studies. The ARSI (C-term) antibody, often raised in rabbits or other host species, is widely used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ARSI expression levels and localization in tissues or cell lines. Its specificity for the C-terminus helps avoid cross-reactivity with other sulfatase family members, ensuring accurate detection in research settings.
Researchers utilize this antibody to investigate ARSI's role in cellular metabolism, lysosomal function, and disease mechanisms, particularly in MLD and cancer studies where sulfatase dysregulation is observed. Its validation in multiple applications and species (e.g., human, mouse) underscores its utility in both basic research and preclinical studies.
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