| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ermin, Juxtanodin, JN, ERMN, KIAA1189 |
| Entrez GeneID | 57471 |
| WB Predicted band size | 32.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ERMIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human ERMIN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ERMIN抗体的3篇示例文献(注：文献为示例性质，非真实存在)：
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1. **文献名称**：*ERMIN: A Novel Protein Essential for Myelin Compaction in Oligodendrocytes*
**作者**：Smith A, et al. (2020)
**摘要**：本研究首次开发了针对ERMIN蛋白的小鼠单克隆抗体，用于检测其在少突胶质细胞中的表达。通过免疫荧光和Western blot分析，发现ERMIN在髓鞘形成过程中高度富集，且其缺失导致髓鞘结构松散。该抗体为研究髓鞘相关疾病提供了关键工具。
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2. **文献名称**：*CRISPR Screening Identifies ERMIN as a Regulator of Myelin Maintenance*
**作者**：Johnson R, et al. (2021)
**摘要**：利用CRISPR-Cas9技术敲除ERMIN基因，结合特异性抗体进行蛋白定位，发现ERMIN缺失引发小鼠运动功能障碍。研究证实该抗体可特异性识别ERMIN的C端结构域，并揭示其在维持髓鞘完整性中的关键作用。
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3. **文献名称**：*ERMIN Antibody-Based Detection of Early Demyelination in Multiple Sclerosis Models*
**作者**：Lee S, et al. (2019)
**摘要**：通过制备兔多克隆ERMIN抗体，本研究在实验性自身免疫性脑脊髓炎(EAE)模型中检测到ERMIN表达显著下调。抗体验证表明其适用于脑组织切片染色，为多发性硬化症的早期诊断提供了潜在标志物。
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**备注**：如需真实文献，建议通过PubMed或Google Scholar以关键词“ERMIN antibody”或“ERMN(ERMIN别名)”检索近年研究。
ERMIN (also known as ermin) is a protein encoded by the ERMN gene, primarily studied in the context of central nervous system (CNS) myelination. Discovered in the early 2000s, it is highly expressed in oligodendrocytes, the glial cells responsible for producing myelin sheaths that insulate neuronal axons. ERMIN contains a JAC (juxta membrane and conserved) domain, which is critical for its role in organizing the cytoskeleton during myelination. Research indicates that ERMIN interacts with actin filaments and membrane proteins, facilitating the structural stabilization of myelin sheaths by promoting membrane compaction and process extension in oligodendrocytes.
Functional studies in mice revealed that ERMN knockout models exhibit hypomyelination, impaired motor coordination, and abnormal myelin ultrastructure, highlighting its importance in CNS development. ERMIN’s dysregulation has been implicated in demyelinating disorders like multiple sclerosis (MS) and psychiatric conditions such as schizophrenia, though exact mechanisms remain under investigation. Recent studies also suggest its potential role in regulating vesicle trafficking and membrane dynamics in myelinating cells. As a relatively novel target, ERMIN antibodies are primarily used as research tools to explore myelination biology and disease pathology. Their development aids in visualizing ERMIN localization, assessing expression levels, and deciphering molecular pathways in neurological disorders. Ongoing research aims to clarify ERMIN’s therapeutic potential in remyelination strategies.
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