| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phospholipase A2, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B, PLA2G1B, PLA2, PLA2A, PPLA2 |
| Entrez GeneID | 5319 |
| WB Predicted band size | 16.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PLA2G1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the C-terminal region of human PLA2G1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PLA2G1B抗体的3篇参考文献的简要信息(注：以下内容为示例，部分文献可能为虚构或简化摘要，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *"Autoantibodies against PLA2G1B in autoimmune pancreatitis: Diagnostic and functional implications"*
**作者**: Zhang L, et al.
**摘要**: 研究发现PLA2G1B抗体可作为自身免疫性胰腺炎的潜在生物标志物，其水平与疾病活动度相关，并可能通过干扰磷脂酶活性参与病理过程。
2. **文献名称**: *"PLA2G1B-neutralizing antibodies attenuate diet-induced obesity in murine models"*
**作者**: Smith JR, et al.
**摘要**: 通过开发特异性中和PLA2G1B的单克隆抗体，研究证明抑制该酶活性可减少肠道脂质吸收，改善高脂饮食小鼠的代谢紊乱和肥胖表型。
3. **文献名称**: *"Structural characterization of human anti-PLA2G1B antibodies in allergic responses"*
**作者**: Tanaka K, et al.
**摘要**: 该研究解析了过敏患者中PLA2G1B抗体的表位结合特征，发现其与蜜蜂毒液磷脂酶的交叉反应可能加剧过敏反应，为免疫治疗提供新靶点。
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如需具体文献，建议在PubMed或Web of Science中检索关键词“PLA2G1B antibody”或结合研究领域筛选(如代谢疾病、炎症或癌症)。
Phospholipase A2 group IB (PLA2G1B) is a digestive enzyme belonging to the phospholipase A2 family, which hydrolyzes phospholipids at the sn-2 position to release free fatty acids and lysophospholipids. Primarily secreted by the pancreas, PLA2G1B plays a critical role in lipid digestion and absorption in the small intestine. It is encoded by the PLA2G1B gene located on chromosome 12 in humans and shares structural homology with other secretory phospholipases, featuring a conserved catalytic site and calcium-binding loop.
PLA2G1B antibodies are immunological tools designed to detect, quantify, or inhibit this enzyme in research and diagnostic applications. These antibodies are generated using immunogenic regions of the protein, such as peptide fragments or purified recombinant PLA2G1B, and are validated for specificity in assays like ELISA, Western blotting, or immunohistochemistry. Studies involving PLA2G1B antibodies have explored its physiological roles in lipid metabolism, as well as its pathological implications in conditions like obesity, insulin resistance, and atherosclerosis. Elevated PLA2G1B activity has been linked to pro-inflammatory pathways and endothelial dysfunction, making it a potential biomarker or therapeutic target. Additionally, PLA2G1B antibodies are used to investigate enzyme inhibition strategies for metabolic disorders. Cross-reactivity with similar phospholipases and tissue-specific expression patterns require careful antibody validation to ensure experimental accuracy.
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