| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitotic interactor and substrate of PLK1, Mitotic spindle positioning protein, MISP, C19orf21 |
| Entrez GeneID | 126353 |
| WB Predicted band size | 75.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C19orf21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human C19orf21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于C19orf21(N-term)抗体的3篇参考文献示例(注：以下内容为模拟生成，非真实文献)：
1. **文献名称**：*C19orf21 interacts with mitotic spindle proteins and regulates cell division*
**作者**：Smith A, et al.
**摘要**：本研究利用C19orf21(N-term)特异性抗体进行免疫沉淀和免疫荧光实验，发现C19orf21蛋白与有丝分裂纺锤体组分(如α-tubulin)存在相互作用，提示其在细胞周期调控中的潜在功能。
2. **文献名称**：*Dysregulation of C19orf21 in colorectal cancer and its clinical implications*
**作者**：Zhang L, et al.
**摘要**：通过C19orf21(N-term)抗体的Western blot和免疫组化分析，作者发现C19orf21在结直肠癌组织中表达显著下调，且低表达与患者不良预后相关，表明其可能作为肿瘤抑制因子发挥作用。
3. **文献名称**：*C19orf21 localizes to the Golgi apparatus and modulates vesicular trafficking*
**作者**：Johnson R, et al.
**摘要**：使用C19orf21(N-term)抗体进行亚细胞定位研究，发现该蛋白主要定位于高尔基体，并通过敲低实验证实其参与调控细胞内囊泡运输过程。
4. **文献名称**：*A novel role of C19orf21 in neuronal development revealed by antibody-based proteomics*
**作者**：Lee S, et al.
**摘要**：结合C19orf21(N-term)抗体的免疫共沉淀和质谱分析，揭示了C19orf21与神经元突触发育相关蛋白的相互作用网络，提示其在神经发育疾病中的潜在机制。
(注：上述文献为虚构，实际研究中建议通过PubMed或Google Scholar以“C19orf21 antibody”或“C19orf21 function”为关键词检索最新文献。)
The C19orf21 (N-term) antibody is a specialized tool designed to target the N-terminal region of the chromosome 19 open reading frame 21 (C19orf21) protein, a relatively understudied protein encoded by the C19orf21 gene. This gene, also known as MICU2 (mitochondrial calcium uptake 2), plays a critical role in mitochondrial calcium homeostasis by regulating the mitochondrial calcium uniporter (MCU) complex. The encoded protein interacts with MICU1 to modulate calcium uptake, ensuring balanced cellular energy production and apoptosis regulation. Antibodies targeting the N-terminal domain are particularly valuable for studying the protein's functional regions, post-translational modifications, or interactions within the MCU complex.
C19orf21 (N-term) antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, subcellular localization (primarily mitochondria), and molecular interactions. Their specificity for the N-terminal region helps differentiate isoforms or truncation variants. Research applications include exploring roles in metabolic disorders, neurodegenerative diseases, and cancer, where mitochondrial calcium dysregulation is implicated. Validation typically involves knockdown/knockout controls or tagged protein overexpression to confirm signal specificity. As C19orf21's functional mechanisms remain partially elucidated, this antibody serves as a key reagent for advancing understanding of mitochondrial physiology and disease-related pathways.
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