| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-lysine methyltransferase SETD6, 211-, SET domain-containing protein 6, SETD6 |
| Entrez GeneID | 79918 |
| WB Predicted band size | 53.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SETD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the C-terminal region of human SETD6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SETD6抗体的3篇参考文献(注：文献信息为模拟示例，实际引用需根据真实论文调整)：
1. **文献名称**：*SETD6 regulates NF-κB signaling via non-catalytic methylation of RelA*
**作者**：Levy D, et al.
**摘要**：本研究利用SETD6特异性抗体，发现SETD6通过甲基化转录因子RelA(p65)调控NF-κB信号通路，抑制炎症基因表达。抗体用于免疫沉淀和染色质分析，证实SETD6在炎症反应中的表观遗传作用。
2. **文献名称**：*SETD6-mediated histone methylation promotes stem cell pluripotency*
**作者**：Zhang Y, et al.
**摘要**：通过SETD6抗体进行染色质免疫沉淀测序(ChIP-seq)，发现SETD6催化H2A.Z的甲基化，维持胚胎干细胞的自我更新能力，揭示其在多能性调控中的关键功能。
3. **文献名称**：*SETD6 deficiency enhances DNA damage response in cancer cells*
**作者**：Wang L, et al.
**摘要**：使用SETD6抗体进行蛋白质印迹(Western blot)和免疫荧光实验，证明SETD6缺失导致DNA修复通路激活，提示其可能作为癌症治疗的潜在靶点。
如需具体文献，建议在PubMed或Web of Science中搜索“SETD6 antibody”或“SETD6 function”获取真实论文。
The SETD6 (SET Domain Containing 6) antibody is a research tool used to detect and study the SETD6 protein, a member of the SET domain-containing methyltransferase family. SETD6 primarily catalyzes the methylation of histone H2A at lysine 7 (H2AK7) and non-histone substrates, such as RelA (a subunit of NF-κB), influencing epigenetic regulation and cellular signaling pathways. It plays roles in gene expression modulation, DNA repair, and cell proliferation, with implications in developmental processes and disease pathogenesis.
SETD6 antibodies are widely employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to analyze protein expression, localization, and interactions. These antibodies help investigate SETD6's involvement in NF-κB signaling, stem cell differentiation, and immune responses. Dysregulation of SETD6 has been linked to cancers, inflammatory diseases, and neurological disorders, making it a potential therapeutic target.
Validated SETD6 antibodies are critical for ensuring specificity in detecting endogenous SETD6. particularly given its low abundance in cells. Researchers rely on these antibodies to explore its methyltransferase activity, substrate specificity, and role in epigenetic and non-epigenetic mechanisms, advancing understanding of its biological and pathological significance.
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