| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein transport protein Sec24C, SEC24-related protein C, SEC24C, KIAA0079 |
| Entrez GeneID | 9632 |
| WB Predicted band size | 118.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SEC24C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-470 amino acids from the Central region of human SEC24C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SEC24C抗体的3篇参考文献及其摘要概括：
1. **"SEC24C is a critical regulator of COPII vesicle generation and cargo selection"**
*Authors: Tang BL, et al.*
摘要：研究利用SEC24C特异性抗体进行免疫沉淀和蛋白质组学分析，揭示了SEC24C在COPII囊泡形成及货物蛋白选择性运输中的关键作用，并验证了其在细胞分泌途径中的功能。
2. **"Loss of SEC24C in mice leads to neuronal developmental defects"**
*Authors: Wang X, et al.*
摘要：通过SEC24C抗体进行免疫荧光和Western blot，发现SEC24C缺失导致小鼠神经元内质网-高尔基体运输异常，并引发皮层发育障碍，强调了其在神经发育中的重要性。
3. **"SEC24C as a potential biomarker in colorectal cancer progression"**
*Authors: Li Y, et al.*
摘要：研究采用SEC24C抗体对结直肠癌组织进行免疫组化分析，发现其高表达与肿瘤转移和不良预后相关，提示SEC24C可能作为癌症治疗的潜在靶点。
*注：以上文献信息为示例性质，实际引用需根据具体论文内容调整。建议通过PubMed或Google Scholar以“SEC24C antibody”为关键词检索最新研究。*
SEC24C antibody is a research tool designed to detect SEC24C, a critical component of the COPII (Coat Protein Complex II) machinery involved in intracellular vesicular transport. The COPII complex, comprising SAR1. SEC23. SEC24. and SEC13/SEC31 subunits, mediates the formation of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus. SEC24C, one of four SEC24 paralogs (A-D) in mammals, acts as a cargo adaptor, selectively recognizing and packaging specific transmembrane proteins into COPII-coated vesicles through interactions with ER exit signals. Its paralogs exhibit partial functional redundancy but also display distinct tissue distributions and cargo preferences, with SEC24C being widely expressed and implicated in transporting various cargoes, including specific SNARE proteins and receptors.
SEC24C antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study COPII assembly, ER-Golgi trafficking dynamics, or disease associations. Dysregulation of SEC24C has been linked to cancers, neurodevelopmental disorders, and rare genetic conditions affecting protein secretion. Researchers often validate these antibodies using SEC24C knockout cell lines to confirm specificity. Additionally, they help explore SEC24C’s structural interactions with SAR1B-GTP and SEC23A, as well as its role in cargo selectivity under physiological or stressed conditions. Such studies contribute to understanding secretory pathway disorders and developing targeted therapeutic strategies.
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