| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphoglycolate phosphatase, PGP, PGPase, PGP |
| Entrez GeneID | 283871 |
| WB Predicted band size | 34.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PGP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human PGP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PGP(N-term)抗体的3篇参考文献，以简化的格式呈现：
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1. **文献名称**: *Characterization of a Novel Anti-PGP9.5 Antibody for Neurodegeneration Research*
**作者**: Smith A, et al.
**摘要**: 该研究报道了一种针对PGP9.5蛋白N端表位的单克隆抗体的开发，通过Western blot和免疫组化验证其在人脑组织中的特异性，证实其适用于检测神经元及轴突损伤。
2. **文献名称**: *PGP9.5 as a Peripheral Nerve Marker: Validation of N-terminal Antibody Specificity*
**作者**: Lee B, et al.
**摘要**: 通过比较PGP9.5不同区域抗体的敏感性，发现N端抗体在小鼠周围神经中的标记效果优于C端抗体，支持其在神经病理学诊断中的应用潜力。
3. **文献名称**: *Role of P-glycoprotein N-terminal Domain in Drug Resistance: Antibody-based Functional Analysis*
**作者**: Chen X, et al.
**摘要**: 研究利用靶向P-gp(P糖蛋白)N端的抗体，证明该区域在肿瘤细胞药物外排中的关键作用，为多药耐药性机制提供了新见解。
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注：以上为虚构示例，实际文献需通过数据库(如PubMed)检索关键词“PGP9.5 antibody N-terminal”或“P-glycoprotein N-term antibody”获取。若需具体文献，请提供更明确的研究背景(如靶蛋白类型或应用领域)。
The PGP (N-term) antibody specifically targets the N-terminal region of the protein gene product 9.5 (PGP9.5), encoded by the *UCHL1* gene. PGP9.5 is a ubiquitin carboxyl-terminal hydrolase involved in ubiquitin recycling and protein degradation, playing critical roles in neuronal function, cellular differentiation, and apoptosis. It is widely expressed in neurons, neuroendocrine cells, and certain tumors, making it a common biomarker for studying neural tissues and neuroendocrine neoplasms.
The antibody's N-terminal specificity ensures recognition of full-length PGP9.5. distinguishing it from degradation products or isoforms. It is extensively used in techniques like immunohistochemistry (IHC) and Western blotting to map protein distribution in tissues, assess neuronal integrity, or diagnose pathologies such as neurodegenerative disorders (e.g., Parkinson’s disease) and cancers (e.g., neuroblastoma).
Originally identified as a neuronal marker, PGP9.5's role has expanded to include immune regulation and cancer biology. The PGP (N-term) antibody thus serves as a vital tool in both basic research and clinical diagnostics, aiding in understanding disease mechanisms and validating therapeutic targets. Its reliability in diverse applications underscores its importance in neuroscience, oncology, and pathology studies. (Word count: 198)
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