| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Estradiol 17-beta-dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-hydroxysteroid dehydrogenase XI, 17-beta-HSD XI, 17betaHSDXI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, retSDR2, HSD17B11, DHRS8, PAN1B |
| Entrez GeneID | 51170 |
| WB Predicted band size | 32.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HSD17B11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human HSD17B11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于HSD17B11(N-term)抗体的参考文献示例(内容为虚构，仅作格式参考)：
1. **"Characterization of HSD17B11 in steroid metabolism using N-terminal specific antibodies"**
- Author: Zhang L, et al.
- 摘要：通过开发HSD17B11的N端抗体，研究其在肝脏组织中的表达及对睾酮代谢的调控作用，证实其参与类固醇激素的局部代谢通路。
2. **"HSD17B11 expression in prostate cancer: A biomarker study"**
- Author: Smith JR, et al.
- 摘要：利用HSD17B11的N端抗体进行Western blot和免疫组化分析，发现该蛋白在前列腺癌细胞中高表达，可能与雄激素信号通路异常相关。
3. **"Functional analysis of HSD17B11 enzymatic activity via immunoprecipitation"**
- Author: Tanaka K, et al.
- 摘要：使用N端特异性抗体富集HSD17B11蛋白，结合质谱技术鉴定其相互作用蛋白，揭示其在氧化还原酶活性中的分子机制。
4. **"HSD17B11 knockdown alters lipid metabolism in hepatocytes"**
- Author: Müller S, et al.
- 摘要：通过RNA干扰及N端抗体验证蛋白敲低效率，证明HSD17B11缺失影响肝细胞脂质代谢，提示其潜在代谢疾病治疗靶点价值。
(注：以上文献为模拟内容，实际引用需查询PubMed等数据库获取真实研究。)
The HSD17B11 (N-term) antibody is designed to target the N-terminal region of the 17β-hydroxysteroid dehydrogenase type 11 (HSD17B11), a member of the 17β-HSD enzyme family. This enzyme plays a role in steroid metabolism, particularly in the regulation of bioactive sex hormones by catalyzing oxidation-reduction reactions. HSD17B11 is implicated in converting less active steroids to their active forms, such as estrone to estradiol, though its precise substrate specificity remains under investigation. The protein is expressed in various tissues, including the liver, kidney, and reproductive organs, and has been linked to metabolic disorders, hormone-dependent cancers, and lipid metabolism regulation.
The N-terminal-specific antibody enables researchers to study HSD17B11's expression, localization, and function in cellular and tissue contexts. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validation often includes reactivity confirmation via knockout/knockdown controls or recombinant protein assays. Research utilizing this antibody has explored HSD17B11's potential role in diseases such as prostate cancer, obesity, and non-alcoholic fatty liver disease (NAFLD), highlighting its importance in metabolic and endocrine pathways. Reliable detection of the N-terminal region ensures specificity, avoiding cross-reactivity with other 17β-HSD family members.
×
