| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Poly(ADP-ribose) glycohydrolase ARH3, ADP-ribosylhydrolase 3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, ADPRHL2, ARH3 |
| Entrez GeneID | 54936 |
| WB Predicted band size | 38.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADPRHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-114 amino acids from the N-terminal region of human ADPRHL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ADPRHL2(N-term)抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需根据具体研究补充)：
---
1. **文献名称**：*Characterization of a Novel N-terminal Specific Antibody for ADPRHL2 in Neurodegeneration*
**作者**：Smith A, et al.
**摘要**：本研究开发并验证了一种针对ADPRHL2蛋白N端表位的多克隆抗体，通过Western blot和免疫荧光验证其特异性，发现ADPRHL2在阿尔茨海默病模型中表达异常，提示其可能与tau蛋白异常修饰相关。
2. **文献名称**：*ADPRHL2 Regulates DNA Damage Repair via PARP1 Signaling*
**作者**：Chen L, et al.
**摘要**：利用N端特异性抗体，作者证实ADPRHL2通过水解ADP-核糖基化修饰参与DNA损伤修复，抗体在HeLa细胞中成功检测到ADPRHL2的核定位及损伤诱导后的表达变化。
3. **文献名称**：*Structural and Functional Insights into ADPRHL2 Catalytic Domain*
**作者**：Wang Y, et al.
**摘要**：通过N端抗体结合质谱分析，研究揭示了ADPRHL2的N端结构对其水解酶活性的调控作用，抗体在蛋白纯化及功能实验中用于验证截短突变体的表达。
---
**提示**：实际文献需通过PubMed或Google Scholar以关键词“ADPRHL2 antibody”“ARH3 antibody”“N-terminal epitope”检索，或参考抗体供应商(如Sigma-Aldrich、Abcam)提供的引用文献。
The ADPRHL2 (N-term) antibody is designed to target the N-terminal region of ADP-ribosylhydrolase-like 2 (ADPRHL2), a protein implicated in cellular stress response and metabolic regulation. ADPRHL2 belongs to the ADP-ribosylhydrolase family, which catalyzes the removal of ADP-ribose modifications from proteins, a post-translational process critical for DNA repair, apoptosis, and signal transduction. While ADPRHL2’s exact biological role remains under investigation, studies suggest it may act as a regulatory enzyme, counterbalancing ADP-ribosylation mediated by PARPs (poly-ADP-ribose polymerases) to maintain cellular homeostasis. Dysregulation of ADP-ribose metabolism is linked to neurodegenerative diseases, cancer, and oxidative stress responses.
The ADPRHL2 (N-term) antibody is commonly used in Western blotting, immunofluorescence, and immunoprecipitation to study the protein’s expression, localization, and interactions. Its specificity for the N-terminal epitope ensures recognition of full-length ADPRHL2. aiding in distinguishing it from potential cleavage products or isoforms. Researchers employ this tool to explore ADPRHL2’s involvement in cellular pathways, including DNA damage repair and metabolic adaptation, particularly under stress conditions. Validation in knockout models or siRNA-treated cells is recommended to confirm signal specificity. As interest in ADP-ribosylation biology grows, this antibody serves as a key reagent for unraveling ADPRHL2’s functional and pathological significance.
×
