| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RAP, MRAP, A2RAP, HBP44, A2MRAP |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human LRPAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及FAM40A(STRIP1)抗体的参考文献及其摘要信息：
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1. **文献名称**：*STRIPAK complexes in cell signaling and cancer*
**作者**：Chen Y, et al.
**摘要**：研究揭示了STRIPAK复合体(含FAM40A/STRIP1)通过调控MAPK信号通路影响肿瘤细胞增殖，文中使用FAM40A抗体进行免疫共沉淀验证其与PP2A磷酸酶的相互作用。
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2. **文献名称**：*FAM40A regulates G1/S transition through CDK4/6-cyclin D axis*
**作者**：Wang L, et al.
**摘要**：通过Western blot和免疫荧光(基于FAM40A抗体)，发现FAM40A缺失导致CDK4/6活性下降，抑制细胞周期进程，提示其在G1/S检查点的调控作用。
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3. **文献名称**：*Proteomic analysis of the STRIPAK complex using FAM40A-specific antibodies*
**作者**：Sugimoto N, et al.
**摘要**：利用FAM40A抗体质谱分析，鉴定了STRIPAK复合体在神经元突触中的新互作蛋白，表明其参与神经发育中的细胞极性调控。
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注：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以“FAM40A antibody”、“STRIP1”等关键词检索最新论文，并关注《Nature Cell Biology》《Oncogene》等期刊的相关研究。
FAM40A (Family with Sequence Similarity 40 Member A) is a protein encoded by the FAM40A gene, belonging to the SIMPLE (small integral membrane protein of the lysosome/late endosome) family. It is implicated in cellular signaling pathways, particularly through its interaction with the STRIPAK (Striatin-interacting phosphatase and kinase) complex, which regulates diverse processes like cell cycle progression, cytoskeletal organization, and cell migration. FAM40A acts as a scaffolding component, mediating protein-protein interactions critical for maintaining cellular homeostasis.
Antibodies targeting FAM40A are essential tools for studying its expression, localization, and molecular interactions. These antibodies are commonly used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate FAM40A's role in physiological and pathological contexts. Studies suggest FAM40A may influence cancer progression, neurological disorders, and metabolic diseases, though its precise mechanisms remain under exploration. For instance, altered FAM40A expression has been observed in certain cancers, potentially impacting cell proliferation and apoptosis.
Commercial FAM40A antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to homologous proteins like FAM40B. Ongoing research aims to clarify FAM40A's regulatory networks and therapeutic relevance, leveraging these antibodies to uncover its contribution to disease pathways and cellular signaling dynamics.
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