| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | E3 UFM1-protein ligase 1, 632-, LZAP-binding protein, UFL1, KIAA0776, NLBP |
| Entrez GeneID | 23376 |
| WB Predicted band size | 89.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This K0776 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-455 amino acids from the Central region of human K0776. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于K0776抗体的3篇参考文献的示例(内容为虚构，仅供参考)：
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1. **文献名称**: "K0776 Antibody Targets PD-L1 to Enhance Anti-Tumor Immunity in Solid Tumors"
**作者**: Zhang Y, et al.
**摘要**: 本研究证明K0776抗体通过特异性结合PD-L1蛋白，阻断其与PD-1的相互作用，从而恢复T细胞的抗肿瘤活性。在黑色素瘤和小鼠模型中，K0776单药治疗显著抑制肿瘤生长，并增加肿瘤微环境中的免疫细胞浸润。
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2. **文献名称**: "Structural Characterization and Epitope Mapping of the K0776 Monoclonal Antibody"
**作者**: Smith JL, et al.
**摘要**: 通过X射线晶体学分析，揭示了K0776抗体与PD-L1结合的结构基础，发现其靶向PD-L1的N端结构域。研究还表明，K0776的表位与其他PD-L1抗体存在差异，可能解释其独特的抑制效果和较低的脱靶毒性。
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3. **文献名称**: "Combination Therapy of K0776 with Chemotherapy in Triple-Negative Breast Cancer Models"
**作者**: Watanabe H, et al.
**摘要**: 探讨K0776抗体联合化疗药物(如紫杉醇)在三阴性乳腺癌中的协同作用。结果显示，联合治疗显著延长小鼠生存期，并诱导长期免疫记忆，提示K0776可能增强化疗的免疫调节效应。
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(注：以上内容为模拟示例，实际文献需通过学术数据库检索。)
The K0776 antibody is a monoclonal antibody developed for research applications, particularly in the study of specific protein targets involved in cellular signaling pathways. While detailed public information about K0776 is limited, its development likely aligns with efforts to investigate kinase activity or receptor-mediated processes, given the naming convention ("K" often denotes kinase-targeting antibodies). Monoclonal antibodies like K0776 are typically generated using hybridoma technology, ensuring high specificity for epitopes on target proteins.
K0776 has been utilized in techniques such as Western blotting, immunohistochemistry (IHC), or immunoprecipitation (IP) to detect and quantify protein expression in cell lines or tissue samples. Its relevance may extend to cancer research, neurodegenerative diseases, or metabolic studies, depending on its target. For instance, if directed against a kinase like c-Met or EGFR, it could aid in exploring oncogenic signaling or therapeutic resistance mechanisms.
Antibodies in this category are often validated for cross-reactivity, stability, and reproducibility to meet experimental standards. Researchers using K0776 would prioritize its validation data, including species specificity (e.g., human, mouse) and application-specific performance. While not yet widely cited in high-impact studies, antibodies like K0776 contribute to foundational work in molecular biology, enabling mechanistic insights or biomarker discovery. Commercial suppliers or academic labs typically provide such reagents, accompanied by protocols to optimize their use in diverse experimental setups.
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