| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FAD-dependent oxidoreductase domain-containing protein 1, 1---, FOXRED1 |
| Entrez GeneID | 55572 |
| WB Predicted band size | 53.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FXRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-377 amino acids from the C-terminal region of human FXRD1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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关于FXRD1抗体的研究目前较为有限，公开数据库中暂未明确匹配的高影响力文献。以下为假设性示例(仅供格式参考，实际文献需通过学术数据库验证)：
1. **"FXRD1 Antibody Characterization in Developmental Biology"**
*Author: Smith A, et al.*
摘要：本研究验证了FXRD1抗体的特异性，并发现FXRD1蛋白在小鼠胚胎发育中调控细胞分化过程，通过免疫组化定位其在神经外胚层的高表达。
2. **"FXRD1 Interaction with RNA Splicing Machinery"**
*Author: Lee J, et al.*
摘要：利用FXRD1抗体进行免疫沉淀，揭示FXRD1与RNA剪接复合体的相互作用，提示其在转录后调控中的潜在功能。
3. **"FXRD1 Dysregulation in Cancer Progression"**
*Author: Chen H, et al.*
摘要：通过Western blot和免疫荧光分析，发现FXRD1在乳腺癌组织中表达上调，可能通过激活Wnt通路促进肿瘤转移。
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**注意**：上述文献为模拟示例，实际研究中可能涉及拼写混淆(如FXR1/FXR2)。建议通过PubMed或Google Scholar检索“FXR1 antibody”或“FXR family antibodies”获取真实文献。若FXRD1为特定研究中的命名，需结合实验上下文或补充基因别名进一步查询。
The FXR1 antibody targets the Fragile X-related protein 1 (FXR1), a member of the Fragile X-related (FXR) family of RNA-binding proteins. FXR1 plays critical roles in mRNA stability, translation, and transport, particularly in muscle, neuronal, and immune cells. It shares structural homology with FMRP (Fragile X Mental Retardation Protein), linked to Fragile X syndrome, but exhibits distinct tissue-specific functions. FXR1 regulates cellular processes such as cell cycle progression, stress response, and synaptic plasticity by interacting with target mRNAs and protein complexes.
Antibodies against FXR1 are widely used in research to study its expression patterns, subcellular localization, and molecular interactions. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation, aiding investigations into FXR1's role in diseases, including muscular dystrophies, cancers, and neurodevelopmental disorders. Commercial FXR1 antibodies are typically raised in rabbits or mice, using immunogenic epitopes from conserved regions of the protein. Validation often involves knockout cell lines or siRNA-mediated knockdown to confirm specificity.
Recent studies highlight FXR1's dual roles as both an oncogene and tumor suppressor, depending on cellular context, making its antibodies valuable tools in cancer research. Additionally, FXR1 dysregulation has been implicated in autoimmune conditions, emphasizing its broad biomedical relevance.
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