| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HO-2 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HMOX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LONP2 (N-term)抗体的模拟参考文献示例(注：内容为假设性概括，建议通过学术数据库核实真实文献)：
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1. **文献名称**：*Mitochondrial protease LONP2 maintains oxidative phosphorylation fidelity through N-terminal degradation of misfolded proteins*
**作者**：Chen, Y. et al.
**摘要**：研究利用LONP2 (N-term)抗体进行免疫沉淀和Western blot分析，揭示LONP2通过降解线粒体错误折叠蛋白维持氧化磷酸化功能，并验证抗体在HeLa细胞中的特异性。
2. **文献名称**：*Development and validation of a polyclonal antibody targeting the N-terminal domain of human LONP2*
**作者**：Martinez, R. et al.
**摘要**：报道一种针对LONP2 N端表位的兔源多克隆抗体的开发，通过免疫组化和小鼠组织切片验证其定位线粒体的能力，并应用于阿尔茨海默病模型中的蛋白表达水平检测。
3. **文献名称**：*LONP2 dysfunction disrupts mitochondrial proteostasis and links to cardiomyopathy*
**作者**：Wang, L. et al.
**摘要**：通过LONP2 (N-term)抗体发现其在心肌细胞线粒体中的高表达，并证明其缺失导致蛋白聚集和心脏功能异常，抗体用于敲除小鼠模型的表型分析。
4. **文献名称**：*Antibody-based profiling of mitochondrial proteases in cancer cell lines*
**作者**：Kim, S. et al.
**摘要**：系统性筛选多种线粒体蛋白酶抗体，包括LONP2 (N-term)，发现其在乳腺癌细胞中表达上调，提示其潜在作为代谢治疗靶点。
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建议通过 **PubMed** 或 **Google Scholar** 检索关键词“LONP2 antibody”、“LONP2 N-terminal”获取真实文献。
The LONP2 (N-term) antibody is a specialized tool designed to detect the N-terminal region of the human LONP2 protein, also known as Lon protease homolog 2. LONP2 is a mitochondrial ATP-dependent protease involved in protein quality control, playing a critical role in degrading misfolded or damaged proteins within the mitochondrial matrix. This enzyme is essential for maintaining mitochondrial homeostasis, energy metabolism, and stress responses. Unlike its paralog LONP1. which is ubiquitously expressed, LONP2 exhibits tissue-specific expression patterns, with higher levels observed in reproductive and certain metabolic tissues.
The antibody is commonly used in research applications such as Western blotting, immunofluorescence, and immunoprecipitation to study LONP2's expression, localization, and functional interactions. Its specificity for the N-terminal region ensures recognition of full-length LONP2 while avoiding cross-reactivity with degradation products or splice variants. Researchers employ this antibody to explore LONP2's involvement in mitochondrial disorders, aging-related pathologies, and diseases linked to proteostatic dysfunction, such as neurodegenerative conditions. Validation typically includes testing in knockout cell lines or tissues to confirm target specificity. By enabling precise detection of LONP2. this antibody supports investigations into mitochondrial proteostasis mechanisms and their broader implications for cellular health.
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