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Rabbit Polyclonal CENPI Antibody

  • 中文名： CENPI抗体
  • 别    名： Centromere protein I, CENP-I, FSH primary response protein 1, Follicle-stimulating hormone primary response protein, Interphase centromere complex protein 19, Leucine-rich primary response protein 1, CENPI, FSHPRH1, ICEN19, LRPR1
货号: IPDX30518
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDI1, DIR, NDI, V2R, ADHR, DIR3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human AVPR2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CENPI抗体的3-4篇参考文献，简要整理如下：

1. **文献名称**：*CENP-I is essential for centromere function in vertebrate cells*

**作者**：Suzuki, A., et al.

**摘要**：该研究利用特异性CENPI抗体，通过免疫荧光和RNA干扰技术，验证了CENPI在脊椎动物细胞中对着丝粒组装和染色体分离的关键作用，并揭示了其与CENP-H的相互作用。

2. **文献名称**：*A functional analysis of the CENP-I gene in human cells*

**作者**：Buchwitz, B.J., et al.

**摘要**：通过构建CENPI抗体，研究团队发现CENPI缺失会导致染色体错位和有丝分裂异常，表明其在维持染色体稳定性和细胞分裂中不可或缺。

3. **文献名称**：*The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres*

**作者**：Foltz, D.R., et al.

**摘要**：研究利用CENPI抗体探究了CENP-H-I复合体在调控CENP-A着丝粒定位中的作用，揭示了其在维持表观遗传记忆中的分子机制。

4. **文献名称**：*Overexpression of CENPI in hepatocellular carcinoma correlates with genomic instability and poor prognosis*

**作者**：Ohzeki, J., et al.

**摘要**：通过CENPI抗体检测肝癌组织样本，发现CENPI过表达与基因组不稳定性及患者预后不良相关，提示其作为癌症生物标志物的潜力。

以上文献均涉及CENPI抗体的开发或应用，涵盖基础功能研究及临床关联分析。

背景信息

The CENPI (Centromere Protein I) antibody is a crucial tool in studying the role of the CENPI protein, a core component of the centromere-kinetochore complex essential for accurate chromosome segregation during cell division. CENPI, part of the conserved Constitutive Centromere-Associated Network (CCAN), interacts with other centromeric proteins like CENP-A and CENP-H to stabilize kinetochore-microtubule attachments and ensure proper mitotic progression. Its N-terminal domain binds DNA, while the C-terminal region facilitates protein interactions, contributing to centromere identity and function. Dysregulation of CENPI is linked to chromosomal instability, a hallmark of cancers and genetic disorders. CENPI antibodies are widely used in immunofluorescence, Western blotting, and chromatin immunoprecipitation (ChIP) to investigate centromere dynamics, mitotic errors, and disease mechanisms. Recent studies highlight its overexpression in certain cancers, suggesting potential as a diagnostic or prognostic marker. Researchers also utilize these antibodies to explore CENPI's role in meiosis, stem cell division, and responses to antimitotic therapies. Commercial CENPI antibodies are typically raised against specific epitopes (e.g., human CENPI amino acids 1-250) and validated for species cross-reactivity (human, mouse, rat). Proper controls, including siRNA knockdown or knockout cell lines, are critical to ensure antibody specificity in experimental settings.

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