| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RNA polymerase II elongation factor ELL, Eleven-nineteen lysine-rich leukemia protein, ELL, C19orf17 |
| Entrez GeneID | 8178 |
| WB Predicted band size | 68.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ELL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human ELL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ELL抗体的示例参考文献(注：以下为虚构示例，建议通过学术数据库查询真实文献)：
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1. **文献名称**：*ELL Protein Function in Transcriptional Elongation and Leukemogenesis*
**作者**：Johnson R, et al.
**摘要**：本研究阐明了ELL蛋白作为RNA聚合酶II延长因子的分子机制，发现其与白血病相关染色体易位(如MLL-ELL融合基因)的关联，并验证了特异性ELL抗体在检测异常蛋白表达中的应用。
2. **文献名称**：*Development of a Monoclonal Antibody for Human ELL and Its Application in Cancer Diagnostics*
**作者**：Chen L, et al.
**摘要**：文章报道了一种高亲和力抗ELL单克隆抗体的开发，通过免疫组化和Western blot验证其在急性髓系白血病样本中的诊断价值，揭示了ELL过表达与预后的相关性。
3. **文献名称**：*ELL Interaction Partners Identified by Co-Immunoprecipitation Using ELL-Specific Antibodies*
**作者**：Martinez P, et al.
**摘要**：利用ELL抗体进行免疫共沉淀筛选，鉴定了ELL蛋白在转录调控复合物中的新型相互作用蛋白，为研究其致癌机制提供了新方向。
4. **文献名称**：*Epigenetic Regulation of ELL Expression in Solid Tumors: Insights from Antibody-Based Profiling*
**作者**：Saito K, et al.
**摘要**：通过ELL抗体分析多种实体瘤样本，发现ELL表达受DNA甲基化调控，并证实其在肿瘤细胞增殖和转移中的潜在作用。
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建议通过PubMed、Google Scholar等平台检索真实文献，关键词：**"ELL antibody"**, **"ELL protein function"**, **"MLL-ELL leukemia"**。
ELL antibodies are immunological tools used to study the ELL protein family, which plays critical roles in transcriptional elongation and RNA processing. The ELL (Eleven-Nineteen Lysine-rich Leukemia) gene was initially identified due to its involvement in chromosomal translocations associated with acute myeloid leukemia (AML). Specifically, the t(7;11)(p15;p15) translocation fuses ELL with the MLL gene, producing an oncogenic fusion protein that disrupts normal transcriptional regulation. This discovery highlighted ELL's importance in hematopoiesis and cancer biology.
ELL proteins (ELL1. ELL2. ELL3) function as RNA polymerase II elongation factors, enhancing transcriptional efficiency by suppressing transient pausing. They also interact with components of the super elongation complex (SEC) and participate in histone modification. ELL antibodies are widely employed in research to investigate these mechanisms through techniques like chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting. Their applications extend to studying developmental biology, cancer progression, and epigenetic regulation.
Commercial ELL antibodies are typically raised against conserved epitopes, enabling cross-reactivity in human, mouse, and rat models. Validation often includes knockout cell line controls to ensure specificity. Recent studies using ELL antibodies have revealed novel roles in stem cell differentiation and stress responses, underscoring their continuing relevance in molecular oncology and gene expression research.
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