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Rabbit Polyclonal COQ5 Antibody

  • 中文名: COQ5抗体
  • 别    名: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, Ubiquinone biosynthesis methyltransferase COQ5, COQ5
货号: IPDX30490
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, Ubiquinone biosynthesis methyltransferase COQ5, COQ5
Entrez GeneID84274
WB Predicted band size37.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis COQ5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-241 amino acids from the Central region of human COQ5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于COQ5抗体的参考文献示例(注:以下内容为模拟生成,非真实文献):

1. **文献名称**:*COQ5 Methyltransferase Activity in Yeast Mitochondria: Role in Coenzyme Q Biosynthesis*

**作者**:Smith J. et al. (2017)

**摘要**:该研究利用COQ5抗体验证了其在酵母线粒体中的定位,证明COQ5通过甲基化修饰参与辅酶Q(CoQ)的生物合成,并揭示其酶活性对线粒体能量代谢的关键作用。

2. **文献名称**:*COQ5 Expression Correlates with Cancer Cell Metabolism and Prognosis in Colorectal Cancer*

**作者**:Lee H. et al. (2019)

**摘要**:通过免疫组化(使用COQ5特异性抗体)分析结直肠癌组织,发现COQ5高表达与肿瘤细胞线粒体功能异常及患者不良预后显著相关,提示其作为潜在生物标志物的价值。

3. **文献名称**:*A Novel COQ5 Mutation Identified in Patients with Primary CoQ10 Deficiency Syndrome*

**作者**:Garcia R. et al. (2021)

**摘要**:研究报道了一种新型COQ5基因突变导致辅酶Q10缺乏症,利用Western blot(COQ5抗体)证实突变引起蛋白质表达下降,为遗传性线粒体疾病的机制提供了新见解。

4. **文献名称**:*COQ5 as a Therapeutic Target: Insights from Antibody-Based Modulation Studies*

**作者**:Chen L. et al. (2023)

**摘要**:综述了COQ5在疾病中的功能,重点讨论其抗体在靶向治疗开发中的应用潜力,包括抑制辅酶Q合成通路以调控细胞代谢的研究进展。

(注:以上文献信息为示例性质,实际引用请通过学术数据库核实真实文献。)

背景信息

The COQ5 antibody is a valuable tool for investigating the COQ5 protein, a critical enzyme in coenzyme Q10 (CoQ10) biosynthesis. COQ5. also known as methyltransferase COQ5. catalyzes the C-methylation step during CoQ10 synthesis, a lipid-soluble molecule essential for mitochondrial electron transport and antioxidant defense. CoQ10. or ubiquinone, is synthesized in the mitochondrial inner membrane, and defects in its production are linked to mitochondrial disorders, neurodegenerative diseases, and age-related conditions. Researchers use COQ5 antibodies primarily to detect and quantify COQ5 expression levels via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These applications help elucidate COQ5’s tissue-specific distribution, subcellular localization, and regulatory mechanisms under physiological or pathological conditions. Additionally, COQ5 antibodies aid in studying genetic mutations associated with CoQ10 deficiencies, which manifest as encephalomyopathy, nephropathy, or cardiomyopathy. Available as polyclonal or monoclonal variants, these antibodies are often validated for specificity using knockout controls or siRNA-mediated COQ5 silencing. Their utility extends to both basic research—exploring mitochondrial dysfunction or oxidative stress pathways—and clinical diagnostics, where COQ5 expression profiling may inform therapeutic strategies targeting CoQ10-related disorders.

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