| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Selenoprotein T, SelT, SELT |
| Entrez GeneID | 51714 |
| WB Predicted band size | 22.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SELT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human SELT. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SELT(N-term)抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**: **"Characterization of a Novel Polyclonal Antibody against the N-Terminus of Selenoprotein T (SELT)"**
**作者**: Martin, J.L. et al.
**摘要**: 本研究开发并验证了一种针对SELT蛋白N端区域的多克隆抗体。通过Western blot和免疫荧光实验，证明该抗体能够特异性识别人类和小鼠组织中的SELT蛋白，并揭示SELT在内分泌组织和神经元中的高表达模式。抗体特异性通过siRNA敲低实验进一步确认。
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2. **文献名称**: **"SELT N-Terminal Antibody Reveals Its Role in ER Redox Homeostasis and Calcium Signaling"**
**作者**: Garcia-Sanchez, A. et al.
**摘要**: 利用针对SELT N端的抗体，研究发现SELT通过调控内质网(ER)的氧化还原平衡和钙离子稳态参与细胞应激响应。抗体在免疫沉淀(IP)和免疫组化中的应用证实SELT与钙通道蛋白的相互作用，提示其在神经退行性疾病中的潜在作用。
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3. **文献名称**: **"Development and Application of an N-Terminal SELT-Specific Antibody for Cancer Biomarker Studies"**
**作者**: Chen, H. & Wang, Q.
**摘要**: 该文献报道了一种高灵敏度的SELT N端单克隆抗体的开发，用于检测多种癌症细胞系和患者组织样本中SELT的表达水平。研究表明，SELT在乳腺癌和结肠癌中显著上调，其表达水平与肿瘤侵袭性相关，提示其作为癌症诊断标志物的潜力。
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**备注**：以上文献为示例性内容，实际文献需通过PubMed、Web of Science等数据库检索关键词(如"SELT antibody N-terminal"或"Selenoprotein T antibody")。若需具体文献，建议结合最新研究进行补充。
SELT (N-term) antibodies are specifically designed to target the N-terminal region of Selenoprotein T (SELT), a member of the selenoprotein family characterized by the presence of selenium in the form of selenocysteine. SELT is a redox-active protein primarily localized in the endoplasmic reticulum (ER) and Golgi apparatus, where it plays a critical role in regulating calcium homeostasis, ER stress response, and cellular redox balance. It is involved in diverse physiological processes, including neuroendocrine secretion, cell adhesion, and hormone biosynthesis. Dysregulation of SELT has been linked to neurodegenerative diseases, metabolic disorders, and cancer, making it a focal point in biomedical research.
The SELT (N-term) antibody is a valuable tool for studying the expression, localization, and function of SELT in various biological contexts. Researchers utilize it in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect SELT in tissue samples or cultured cells. Its specificity for the N-terminal domain ensures minimal cross-reactivity with other selenoproteins or unrelated proteins. Validated in multiple species, including humans, mice, and rats, this antibody aids in elucidating SELT’s role in cellular stress adaptation, secretion pathways, and disease mechanisms. By enabling precise detection, it supports investigations into how SELT contributes to ER function, antioxidant defense, and its potential as a therapeutic target.
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